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Neutrophil elastase has been implicated in the development of pulmonary emphysema, although a function for cathepsin G has not yet been elucidated. Both enzymes are normally tightly controlled by plasma proteinase inhibitors. However, this proteinase-proteinase inhibitor balance can be perturbed in favor...
N. (1996) The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. J. Mol. Biol. 261, 267-278Fujinaga, M.; Chernaia, M. M.; Halenbeck, R.; Koths, K.; James, M. N. G.; The crystal struture of PR3, a neutrophil serine ...
1b,c). In order to find a positive marker for the differentiation of PLB-985 cells, the expression of another human neutrophil surface marker CD11b on differentiated cells was investigated by flow cytometry. Surface markers were detected on day 3 and day 6 of differentiation, isolated human ...
Hansen G, Gielen-Haertwig H, Reinemer P, Schomburg D, Harrenga A, Niefind K. Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor. J Mol Biol 2011;409:681-91....
of a sequence diverse panel of MC4R-specific, potent and full agonistic nanobodies. We solve the active state MC4R structure in complex with the full agonistic nanobody pN162 at 3.4 Å resolution. The structure shows a distinct interaction with pN162 binding deeply in the orthosteric ...
A recent study showed that human neutrophils responded to LPS O128:B12 but not to the other four tested E. coli-derived LPS serotypes by releasing neutrophil extracellular traps (NETs) [19]. It is often speculated that variable responses are linked to differences in the used LPS serotypes ...
a BNNR design predicated on kernel similarity (VDA-GBNNR) is recommended to predict feasible anti-SARS-CoV-2 medications. VDA-GBNNR is compared with four existing advanced level methods under fivefold cross-validation. The results reveal that VDA-GBNNR computes better AUCs of 0.8965, 0.8562,...
Enzyme Number of amino acids in domain Catalytic Linker Haemopexin Terminal MMP-1 Fibroblast collagenase 161 17 189 3 MMP-8 Neutrophil collagenase 163 17 186 3 MMP-13 Collagenase 3 161 18 188 0 MMP-2 Gelatinase (72 KDa) 336 23 192 0 MMP-9 Gelatinase (92 KDa) 337 63 189 3 MMP-3...
Anastellin (AN), a fragment of the first type III module in fibronectin (FN), initiates formation of superfibronectin, a polymer which resembles the native cell-derived fibrillar FN found in the extracellular matrix of many tissues, but which displays remarkably different functional properties. Her...