A kinematic structure refers to the underlying skeletal framework of a moving entity, such as a human or an animal, which is reconstructed from 3D shape sequences obtained from multiple views. It involves initializing the structure independently at each frame to enable robust tracking and estimation...
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure–function relatio...
At least one pigment, with Amax no longer than 415 nm, may be inferred since: short-wavelength sensitivity survives bleaching by long-wavelength light and, thus, does not depend on an absorption side- band of a long-wavelength pigment or an interaction between long-wavelength mechanisms; and ...
2,3,4,5, using laboratory tasks where animals perform a priori defined subsets of behaviors in response to experimenter-defined stimuli6. While such approaches bring essential reliability and control, they also restrict the scope of actions animals...
Ubiquitin-dependent protein degradation is a widespread mechanism regulating virtually every cellular function.1 The selectivity of this proteolytic process is exquisitely controlled by the specific degradation signal, also known as “degron,” which is encoded in the substrate protein and perceived by its...
For large groups of cells, or for unlabeled single-cell data sets, we randomly subsampled the cells to reduce t-SNE runtime (when cells number in the thou- sands, it is nearly impossible to distinguish individual cells in the Structure plot any- how). Even with this subsampling, the ...
Dropouts distort gene expression and misclassify cell types in single-cell transcriptome. Although imputation may improve gene expression and downstream analysis to some degree, it also inevitably introduces false signals. We develop DISC, a novel deep l
For large groups of cells, or for unlabeled single-cell data sets, we randomly subsampled the cells to reduce t-SNE runtime (when cells number in the thousands, it is nearly impossible to distinguish individual cells in the Structure plot anyhow). Even with this subsampling, the Structure ...
The CST–Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST–Polα/primase, captured prior to catalysis in a recruitmen
More than 2000 species of EMFs have been identified to date [37]. EMFs as a branch of traditional Chinese herbal medicine, also played a vital role in the prevention and control of virus for a long history, such as, this COVID-19 outbreak [36]. As early as the Eastern Han Dynasty (...