The quaternary structure of a protein refers to the arrangement of multiple protein chains or subunits, held together by hydrogen bonds and van der Waals forces, to form a functional protein. Any changes in this arrangement can significantly affect the protein's biological activity. ...
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure
Human emotions fluctuate over time. However, it is unclear how these shifting emotional states influence the organization of episodic memory. Here, we examine how emotion dynamics transform experiences into memorable events. Using custom musical pieces a
Honeycomb sandwich panels and shells are composed of face sheets of A 7075-T6 or A 2024-T3, and honeycomb core of A 5052 or A 2024. Composite materials are also used for the core, but the aluminum core is selected when the higher thermal conductivity between the face sheets is needed. ...
Here we first grow three Medicago genotypes from natural populations in each of two native soils in a common garden experiment to ask: (1) To what extent do plant genotype and soil origin structure the microbiome? (2) Do plant compartments (rhizosphere, root endosphere, nodule endosphere, ...
The system and method utilizes a plurality of test devices, each having certain differences in structure, which are fabricated onto a common integrated circuit substrate for contemporaneous testing of each device under controlled quantitative conditions. The test results may be organized into a matrix ...
Structure-based drug design (SBDD) aims to design small-molecule ligands that bind with high affinity and specificity to pre-determined protein targets. Generative SBDD methods leverage structural data of drugs with their protein targets to propose new d
et al. Structure and dynamics of water dangling OH bonds in hydrophobic hydration shells. Comparison of simulation and experiment. J. Phys. Chem. A 115, 6177–6183 (2011). Article CAS PubMed Google Scholar Kronberg, R., Lappalainen, H. & Laasonen, K. Revisiting the Volmer–Heyrovský...
As a controlled experiment with statistical analysis, we have taken rigorous measures to address conclusion validity regarding data treatment and assumptions, number of repetitions and tests needed. For the internal validity of this experiment, it is often difficult to represent a defect at a high ab...
Systems Biology develops computational models in order to understand biological phenomena. The increasing number and complexity of such “bio-models” necessitate computer support for the overall modelling task. Computer-aided modelling has to be based o