2014. The maintenance of chromosome structure: Positioning and functioning of Smc complexes. Nature Reviews Molecular Cell Biology, 15(9): 601-614.Jeppsson K, Kanno T, Shirahige K, Sjogren C. The maintenance of chromosome structure: positioning and functioning of SMC complexes. Nature reviews ...
Structural maintenance of chromosomes (SMC) complexes — cohesin, condensin and the SMC5/6 complex — regulate sister chromatid cohesion, chromosome condensation, and DNA replication, repair and transcription. Insights into how they may execute such a ra
Genome maintenance requires various nucleoid-associated factors in prokaryotes. Among them, the SMC (Structural Maintenance of Chromosomes) protein has been thought to play a static role in the organization and segregation of the chromosome during cell division. However, recent studies have shown that ...
Chromosome structure refers to the arrangement of DNA double-helix backbone in a chromosome, where it extends uninterrupted from one end to the other, including the centromere. In the cell cycle, the chromosome duplicates and consists of two identical chromatids in the G2 stage. A break in the...
The current understanding of the biochemical properties and biologica l functions of SMC proteins is summarized in this paper.关键词: structural maintenance of chromosome proteins condensins cohesins 被引量: 2 年份: 2001 收藏 引用 批量引用 报错 分享 ...
(1998) The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible ... Melby,T. E. - 《Journal of Cell Biology》 被引量: 625发表: 1998年 A Direct Approach to the Structure of Eukaryotic Chromosomes Detail...
A total of 134 of the 307 genes have published knockout mouse models, 76 of which have no reported integument phenotype. For example, one of the genes that does not have a published knockout mouse strain, structural maintenance of chromosomes 3 (Smc3), is known to be associated with ...
As a structure persistent through the mitotic cycle, it provides a mechanism for the maintenance of the linear order of the genes, its chromomeric organization furnishing morphological evidence of its linear differentiation. Other theories of chromosome structure, which regard the chromonema as ...
chromosomal proteins: the various roles of SMC (Structural Maintenance of Chromosome) proteins (V. Schubert), male specific lethal 2 (msl2) in Drosophila (X. Sun and J.A. Birchler), and a protein specific for the nuclear matrix attachment region (MAR) of chromosomal DNA (A.S. Kukalev ...
Polycomb group of genesCATCH22 syndromeThe Polycomb group of (Pc-G) genes and trithorax group of genes are known to play a crucial role in the maintenance of the transcriptional repression state of Hox genes, probably through modification of the chro-matin configuration. The rae28/mph1 gene ...