Academic Press, London, United Kingdom.Gorelick F, Jamieson J (2012). Structure-function relationship in the pancre- atic acinar cell. In: Physiology of the Gastrointestinal Tract, ed. L Johnson, San Diego, CA: Academic Press, 1341-1360....
biological materials; multifunctionality; multiscale structure; bioinspiration; structure–function relationship1. Introduction Natural evolution has equipped biological materials in organisms with complex structures and functions that enable them to flourish in harsh environments over hundreds of millions of ...
All spiders produce protein-based biopolymer fibres that we call silk. The most studied of these silks is spider dragline silk, which is very tough and relatively abundant compared with other types of spider silks. Considerable research has been devoted
Structure–Function Relationship in UCP1 Abstract The function of uncoupling protein (UCP1) as a H+transporter regulated by nucleotide binding is elucidated. H+transport requires fatty acids (FA) with relatively wide structural tolerance. The nucleotide binding site is specific for purine nucleotides a...
These functional rescues, combined with structural evidence (Fig.3eand Extended Data Fig.8b,c), demonstrate a fundamental sequence–structure–function relationship of intrinsic ER disorder. Single-site phosphorylation on disordered ER-NTD alters hydrophobic clustering, leading to significant structural and...
The Na+/K+ Pump: Structure and Function of the Alpha-Subunit Major, functionally relevant features of Na+/K+-ATPase are located on the α-subunit of the αβ-heterodimer. They include the binding sites for the transp... Larisa,A.,Vasilets,... - 《Cellular Physiology & Biochemistry》 ...
whose aggregate formation is necessary for molecular chaperoning activity. Isolation and characterization of α-crystallin from a wide range of vertebrates will help in understanding a better structure–function relationship in a broader sense, which is yet to be achieved. The stability, structure, aggr...
For gaining insight into the structure- function relationships, above all adequate and specific assays have to be available to probe the function. Very often, however, functions are tested in complex systems that do not permit discrimination according to all structural parameters. To study the ...
This correlation has represented a focal point in AMP studies and has been reported as the “AMP structure–function relationship.” Studies focusing on the development of more efficient AMPs with improved antimicrobial activity have proposed a series of rational design strategies, which mainly involve...
Furthermore, in the absence of any stimulus, RI-3 did not change the phosphorylation of p38 MAPK and PI3K/AKT protein kinases33. The pattern of activities of RI-3 prompted us to investigate the structure-function relationship between FPR1 and the fMLF, SRSRY and RI-3 peptides. This ...