The proposed integrated function structure and object-oriented design framework improves the function structure approach, and provides methods of generating variant and common components for the product family. This framework integrates the function structure, object model, and system architecture to explore...
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. PLoS Pathog. 5, e1000259 (2009). PubMed PubMed Central Google Scholar Cherepanov, P. et al. Solution structure of the HIV-1 integrase-binding ...
While the link between brain structure and function remains an ongoing challenge, the prevailing hypothesis is that the structure-function relationship may itself be gradually decoupling from unimodal to transmodal cortex. However, this hypothesis is con
aIn biological materials, structure and function are integrated at all scales, starting from submicron features. The understanding of these features and their relations to the materials overall response and motion is fundamentally critical in developing new bioinspired and hybrid material systems. Below is...
Proper control of the integrated transport systems requires precise coordination of Na,K-pump function with that of a number of other structures. In contrast to the detailed information available about the structure and function of the pure renal Na,K-pump, little is known about the structure of...
Given two models that semantically overlap, what would an integrated model look like? Again, the formal semantics of the model’s components is needed in order to automate this task. Model use In order to simulate and predict the behaviour of a biological system the bio-model has to be impl...
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Results and discussion The N‑terminal extension of INF2 is organized into two α‑helices Human INF2 has a 35-amino-acid-long extension at the N-terminal end whose structure and function are unknown, while the extension present in mDia1 is longer and contains a part, called ...
1c). Within-subject variation over time was consistently lower than between-subject variation, both in organismal composition and in metabolic function (Fig. 1d). The uniqueness of each individual’s microbial community thus seems to be stable over time (relative to the population as a whole),...
integrated usingXDS47and scaled usingSCALA48,49. Intensities were converted to structure factor amplitudes using the programTRUNCATE49,50. Supplementary TableS1summarizes data collection and processing statistics for the two data sets. Structure determination and refinement...