Div., Ciba-Geigy Corp., Summit, NJ 07901, USAJohn Wiley & Sons, Ltd.ChemInformBohacek, R. S., McMartin, C., and Guida, W. C. (1996). The art and practice of structure-based drug design: a molecular modeling perspective. Med. Res. Rev. 16, 3-50....
" said study co-author David Weber, PhD, a professor of biochemistry and molecular biology and director of the Center for Biomolecular Therapeutics at UMSOM, in a press release. "These structures will be important for targeting this human pathogen using structure-...
AD. Treating the EGCG binding position as a pharmacophore, we computationally screened thousands of drug-like compounds for compatibility for the pharmacophore, discovering several that experimentally disaggregate brain-derived tau fibrils in vitro. This work suggests the potential of structure-based, ...
We previously demonstrated that a transmission electron microscope (TEM) operating at 200 keV equipped with a K2 Summit direct electron detector (DED) could be used to resolve a ~150 kDa protein complex to ~2.6 Å using conventional defocus-based SPA methods12. Here, we expand upon ...
structure-based drug development pipelines available to our partners in the future. 29 march 2024 events puxano ceo wouter van putte speaks at euro hpc summit eurohpc users: how are they exploiting the current eurohpc systems & will exploit future exascale capabilities? read more... 30 ...
Selection and Design of a Chimpanzee Env-Derived Trimer Immunogen templates based on native-like Env trimers offer potential for HIV vaccine development, as they display bnAb epitopes and largely occlude non-native epitopes. However, it remains challenging to induce an epitope-focused bnAb response...
掌桥科研 Semantic Scholar ResearchGate summit.sfu.ca (全网免费下载) core.ac.uk (全网免费下载) 查看更多 相似文献 参考文献HYPROSP II--a knowledge-based hybrid method for protein secondary structure prediction based on local prediction confidence. MOTIVATION: In our previous approach, we proposed a hy...
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates signals from growth factors, cellular energy levels, stress and amino acids to control cell growth and proliferation through regulating translation, autophagy and metabolism. Here we determined the cryo-electron microscopy structure of...
structure as the thread subunit Saci_0406. The first 7 amino acids after the N-terminal signal peptide Sec/SPI processing site are also identical, including the isopeptide Asp24 and a very conserved YYY motif (Supplementary Fig.13). Based on the conserved Asp24, we hypothesise that the ...
Selection and Design of a Chimpanzee Env-Derived Trimer Immunogen templates based on native-like Env trimers offer potential for HIV vaccine development, as they display bnAb epitopes and largely occlude non-native epitopes. However, it remains challenging to induce an epitope-focused bnAb response...