Structure, Manufacture, and Uses of Peptides that Can Penetrate Human-derived Cells Conjugated to Specific Biologically Active Charging PeptidesEmbodiments disclosed herein provide compositions for conjugates, including fusion proteins, and methods of using them to treat a variety of conditions. In some ...
Recently, an all-atom version of RoseTTAFold has been developed. RoseTTAFold All-Atom (RFAA)14 allows for predicting proteins in combination with ligands and other biomolecules. The SR on the PoseBusters’ test set13 for protein-ligand prediction is 42%, but it is not known how well the ...
Our SiteInterlock approach uses rigidity theory to efficiently measurethe relative interfacial rigidity of a series of small-molecule ligand orientations andconformations for a number of protein complexes. In the majority of cases, SiteInterlock detects a near-native binding mode as being the most ...
Protein Structure and Function David P. Clark, Nanette J. Pazdernik, in Molecular Biology (Second Edition), 2013 1.6 Quaternary Structure of Proteins Many proteins consist of several individual polypeptide chains. This is especially true of proteins whose total molecular weight is much greater than...
PROSPECTOR (PROtein Structure Predictor Employing Combined Threading to Optimize Results) is a new threading approach that uses sequence profiles to genera... JS And,D Kihara - 《Proteins Structure Function & Bioinformatics》 被引量: 314发表: 2001年 Automated prediction of protein function and detecti...
cns [22] and refmac [39], which both use a maximum likelihood target function, are currently the refinement packages that are most used. The former now provides a complete package for the solution of protein crystal structures and uses the well known refinement techniques from x-plor. Rece...
Highly structured RNAs bind a large amount of proteins With the aim of studying how RNA structure influences protein binding, we measured the amount of double-stranded regions of the human transcriptome8(Fig.1a). We first grouped the RNAs, as detected by enhanced crosslinking and immunoprecipitatio...
Identifying protein interfaces can inform how proteins interact with their binding partners, uncover the regulatory mechanisms that control biological functions and guide the development of novel therapeutic agents. A variety of computational approaches have been developed for predicting a protein’s interfaci...
The plot uses f as horizontal Axis y as vertical axis. The (, ) angle for each residue can be entered on the plot. For folded proteins, their (, ) angles cluster in few regions of the plot. The upper left corner are beta-sheet values and middle left are a-helices values. Lines ...
For example, ‘A3B2C2’ means the complex contains three different protein chains, A, B and C, and there are three copies of protein A, two copies of protein B and two copies of proteins C in this complex. For homomers, the dataset contains twenty-two ‘A2’ (dimer), thirteen ‘A3...