Cells access the information stored in DNA by creating RNA to direct the synthesis of proteins through the process oftranslation. Proteins within a cell have many functions, including building cellular structure
RNA polymerase synthesizes RNA from DNA that is functionally for protein-coding (messenger RNA, mRNA) or non-coding (RNA genes). Because of these functions, RNA molecules are of following types: messenger RNA (mRNA) –It is the RNA that carries information from DNA to the ribosomes (site ...
RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing ...
The major determinant of small RNAs that functions as specific triggers of gene silencing is the A-form helical geometry of RNA. The A-form helix and high-resolution structural studies provide a context for discussing the importance of phosphate groups at the 5′ end of the guide strand. ...
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a u
transfer RNA nearly thirty years ago (Robertus et al., 1974), it is now widely recognized that all classes of biological RNA molecules fold into complex three-dimensional shapes and structures in order to carry out their diverse biological functions Doudna and Cate 1997, Hermann and Patel 1999...
A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhi...
RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA structuromes, have been developed. Applications of these approaches to different cell lines and tissues have genera...
The major determinant of small RNAs that functions as specific triggers of gene silencing is the A-form helical geometry of RNA. The A-form helix and high-resolution structural studies provide a context for discussing the importance of phosphate groups at the 5′ end of the guide strand. ...
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure