Acta Crystallogr. Sect. F Struct. Biol. Commun. 71, 1318-1321. http://dx.doi.org/10.1107/S2053230X1501643X.Valkov,E. and Stewart,M. (2015). 1.25 A˚ resolution structure of an RNA 20-mer that binds to the TREX2 complex. Acta Crystallogr. F Struct. Biol. Commun. 71, 1318-21....
nucleoporins, and Ran system proteins. A holistic view of the NTS could facilitate the understanding of relevant phenomena and guide the development of therapies for diseases. In this review, we will explore the structure, function,
Our structural data further allow us to map the location of disease-associated NF1 variants and provide a long-sought-after structural explanation for the extreme susceptibility of the molecule to loss-of-function mutations. Collectively these findings present potential new routes for therapeutic ...
POGLUTs use both Notch and TGF-β1 pathway to manipulate the expression of CDKIs and, in turn, function in a cell type-dependent manner. Their overexpression increases cell proliferation in some cells, while inhibiting cell growth in other cells. Open questions Why and how can POGLUT1 display...
Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better ...
SUHs are membrane-associated enzymes and are expressed in the midguts of these lepidopterans, where GH32 β-fructofuranosidase is also expressed, to digest sucrose (8, 36). There were very few studies on structure–function relationships of insect GH13 enzymes; the structures of GH13_15 α-...
The starch debranching enzymes isoamylase 1 and 2 (ISA1 and ISA2) are known to exist in a large complex and are involved in the biosynthesis and crystallization of starch. It is suggested that the function of the complex is to remove misplaced branches of growing amylopectin molecules, which ...
and maintain a balance of the cellular Ub pool. In addition, some DUBs prefer to cleave poly-Ub chains not linked through the conventional K48 residue, which often alter the substrate activity instead of its stability. In plants, all seven known DUB subfamilies have been identified, namely Ub...
Despite the glucosyltransferase activity, POGLUTs can also act as xylosyltransferases, i.e., adding Xyl from UDP-Xyl onto a serine residue. POGLUTs use both Notch and TGF-β1 pathway to manipulate the expression of CDKIs and, in turn, function in a cell type-dependent manner. Their overex...
RNase MRP is an essential eukaryotic ribonucleoprotein complex involved in the maturation of rRNA and the regulation of the cell cycle. RNase MRP is related to the ribozyme-based RNase P, but it has evolved to have distinct cellular roles. We report a cr