Time seriesSimilarity SearchFor more than one decade, time series similarity search has been given a great deal of attention by data mining researchers. As a result, many time series representations and distance measures have been proposed. However, most existing work on time series similarity ...
Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We develop two deep learning methods to address this gap, TM-Vec and DeepBLAST. TM-Vec allows searching for structure–...
An overall goal of SG is to deduce function based on structural similarity to characterize proteins, incorporating any information from endogenous ligands, so as to propose testable hypotheses on its specific function in the cell. Sign in to download full-size image Figure 1. Structural genomics. ...
Clearly, mutual information can also be used in our case as a nonlinear similarity measure instead of Pearson correlation33. However, for the type of data considered in this section, i.e. time series of stocks, the typical measure used in the literature is Pearson correlation. This is due ...
The processing phase described in the paper can be divided into two operations: (1) time-series clustering and (2) time-series prediction/forecasting. Clustering aims at creating groups of time-series based on some similarity measures. As the different time-series correspond to vertical displacement...
based on similarity is the encoder–decoder LSTM implemented in[114]. This method predicts the health index curve based on the autoencoder reconstruction error and estimates the RUL based on the similarity of the curve predicted with train instances without making assumptions on the degradation trend...
coded by ~4% of the protein-coding genome and targeted by ∼34% of marketed drugs2. Despite their low sequence similarity, GPCRs share a common barrel tertiary structure consisting of seven transmembrane helices (TM1–TM7) that host the orthosteric binding site—the binding site of endogenous...
Nevertheless, sequence similarity to standard vertebrate globins, such as Hb α, β chains, myoglobin (Mb), neuro- and cyto-globin (Ngb and Cygb) can be detected [11], despite the presence of additional interhelical, N- and/or C-terminal extensions. The intron/exon patterns of these C....
7a). Coupled with the structural similarity of axial stacking interactions between the Form I-like and Form II-like assemblies, these results provided further support that the helix-helix interactions along the axial interface were natively designable (Fig. 6c). Fig. 7: Cryo-EM of the ...
which presented a highly similar pattern (Fig.1b). Particularly, the regional pairs with strong connectivity in the BOLD FC also presented strong connectivity in the SEEG FC. We next used Spearman’s rank correlation to evaluate the similarity between the two FC matrices as the FC was not nor...