This paper presents results of researches integrated influences on biological systems. To describe different range of signals, the concept "Biological Scale" is introduced. "Biological Scale" incorporates data ranging from whole body through to data at the genes levels, and even the quantum and ...
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Untargeted metabolomics experiments rely on spectral libraries for structure annotation, but, typically, only a small fraction of spectra can be matched. Previous in silico methods search in structure databases but cannot distinguish between correct and incorrect annotations. Here we introduce the COSMIC ...
Two different tests were performed to obtain residual stress levels in longitudinal and circumferential directions: axial pre-stretch test and ring opening test, respectively. Many studies have presented the impact of the longitudinal stretch in the arterial mechanics, whose effect is essential to reach...
Notably, the base and head are connected by a long arch-like protein (Figure 4A). Upon using different contour levels for displaying the cryo-EM density, a considerable amount of the mass in the periphery appeared indeed flexible despite the overall rigidity of the core (Figure S4). ...
Study of Critical Dimension and Overlay Measurement Methodology Using SEM Image Analysis for Process Control As the design rule of semiconductor devices shrinks to below 100nm dimensions, the degree of pattern alignment from different process levels has become a c... TY Lee,BH Lee,SB Chin,... ...
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Structural variants (SVs) are a major source of human genetic diversity and have been associated with different diseases and phenotypes. The detection of SVs is difficult, and a diverse range of detection methods and data analysis protocols has been deve
ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes, showing how ClpA pore loops interact with the ClpS N-terminal extension (NTE
Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we report the cryo-EM structure of full-length IGF1R–IGF1 complex in th