These structures have led to insights into the biology of the organism, and several are currently being pursued as drug targets in active inhibitor discovery campaigns. A Targeting Proteins of Functional Importance The large number of genes within a given organism makes it nearly impossible to ...
摘要: By mid-2007, the three-dimensional (3D) structures of some 45,000 proteins have been solved, over a period where the linear structures of millions of genes have been defined. Technical challenges...关键词: Crystallography Database annotation Gene function Protein structure Protein–protein ...
Here, the authors map X-chromosome activity during female mouse germ cell reprogramming, revealing gradual, region-specific gene reactivation. Some genes resist reactivation, retaining epigenetic memory, offering insights into female germline epigenetics. ...
Antibody diversification relies on the intentional mutagenesis of immunoglobulin genes for adaptive immune responses. Here, the authors identified a CTLH E3 ubiquitin ligase complex that co-opts FAM72A to recruit and degrade the UNG2 base excision repair factor to permit mutagenesis. Philip Barbulescu ...
which are genes or encoded proteins that have a common conserved function since theirlast common ancestor. This contrasts with the definition of orthologs where only the evolutionary history is concerned (Haftet al., 2003); as such equivalogs may include more than orthologs (i...
the identification of genes that have been important for human-specific evolution. to check access. We are most grateful to JP Demuth and MW Hahn for their personal communication of as yet unpublished data. We would also like to thank Violaine Goidts, Justyna Szamalek, Catharina Sandig, ...
Within exons, the largest number (749, 0.6%) of SVs were found within 3′Rglt(Wk) regions of 595 (0.5%) genes, suggesting that SVs could more likely fine-tune genes’ function by interrupting their 3′-UTR (Fig. 2c). The singleton SV proportion can reflect the diversity of a region...
ERG, PTEN, CSMD3 and LRP1B were previously identified as driver genes associated with PCa using this sample data source and PCAWG cohorts [6], while our new method highlighted 18 additional potential driver genes, including GABRB1, CLVS1, RNLS, TMPRSS2, TTC28, EYS, TTC6, PTPRD, PRKN,...
Here, the authors examine and discuss the functional complexity and cellular implications of X–Y pairs, homologous genes expressed in the human sex chromosomes. Michael C. Owens Amber Yanas Kathy Fange Liu Review Article09 Aug 2024 The impact of DNA methylation on CTCF-mediated 3D genome organi...
Under our definition, a genetic interaction was assigned to a pair of genes (a,b) if W ab , the cell viability of the double knockdown, was significantly different from E(W ab ), the viability of the double knockdown that would be expected if a and b were noninteracting. The expected...