A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell 53, 753–768 (1988). Article CAS PubMed Google Scholar Walworth, N.C., Goud, B., Kabcenell, A.K. & Novick, P.J. Mutational analysis of SEC4 suggests a ...
1983. Plant cell extension: structural implications for the origin of the plasma membrane. Plant, Cell and Environment 6, 429-32.Quaite E, Parker RE, Steer MW (1983) Plant cell extension: struc- tural implications for the origin of the plasma membrane. Plant Cell Environ 6: 429-432...
Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution By combining genome-wide clustered regularly interspaced short palindromic repeats with Cas9 screening and cryo-electron microscopy structure analysis, the authors identified transmembrane protein 63B as a lip...
Molecular dynamics simulations combined with site-directed mutagenesis and functional assays allow dissection of the binding interactions of TgPLP1 and PvPLP2 on lipid bilayers, and reveal similar tropisms for lipids enriched in the inner leaflet of the mammalian plasma membrane. In addition PvPLP2 ...
The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane. Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface...
A domain usually overlooked while evaluating CAR functionality is the hinge domain (HD). The HD in CARs serves as a spacer that holds scFvs beyond the plasma membrane and gives them the flexibility necessary to access antigen epitopes on the surface of target cells [77,78]. The origin, leng...
The discovery of dystrophin and its definition as the causative molecule in Duchenne Muscular Dystrophy has led to a renewed interest in the molecular structure of the muscle fiber plasma membrane and its association with the extracellular basal lamina. The original identification of dystrophin gave cre...
Rosenbluth J: Subsurface cisterns and their relationship to the neuronal plasma membrane. J Cell Biol. 1962, 13: 405-421. 10.1083/jcb.13.3.405. Article PubMed Central CAS PubMed Google Scholar Bolton PF, Park RJ, Higgins JN, Griffiths PD, Pickles A: Neuro-epileptic determinants of autism...
Originally discovered in the circulation of pregnant women as a protein secreted by placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP-A) is also widely expressed by many other tissues. It cleaves insulin-like growth factor-binding proteins (IGFBPs) to increase th...
We proposed that binding of this monomer to phospholipid surface, possibly mediated by ABCA1 transporter that can dimerize in the plasma membrane (71), is accompanied by apoA-I dimerization and lipid sequestration via the hydrophobic C-terminal segment 8–10 that forms the primary lipid-binding ...