R. The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie 134, 35–50 (2017). Article CAS PubMed PubMed Central Google Scholar Fromme, T. et al. Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity...
b Cylinder representation of the CeOTOP8 dimer structure at pH 8.0 in top and side views. Numbers mark the TM helices of one subunit. Dotted ovals enclose the structural features unique in CeOTOP8. The extended TM5 helix at pH 8 is colored in hot pink. c Superimposition between the N-...
Variation in the Calpain-10 Gene Is Associated with Elevated Triglyceride Levels and Reduced Adipose Tissue Messenger Ribonucleic Acid Expression in Obese ... Our aim was to investigate the possible role of the type 2 diabetes susceptibility gene CAPN10 in obesity. A case control study consisting ...
Four methods were used to assess the quality of these two novel assemblies. First, the Benchmarking Universal Single-Copy Ortholog (BUSCO) [18] analysis based on the mammalia_odb9 database showed that 93.8% and 93.2% of single-copy genes were identified in Hainan_v1 and Mongolian_v1, resp...
Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal ...
Primarily as a consequence of the fast sequence evolutionary rate of mouse, the pig has remained considerably more similar at the DNA sequence level to humans [16]. However, some immunological features are exceptional in the pig compared to humans and mice. Pigs have an inverted lymph node ...
1B). Sequence alignments reveal that LCN2-R, however, exhibits atypical features, as the first TM is not present, and the sequence of the 100 following residues, until TM2, significantly differs from the canonical SLC22 sequence (Fig. 1A). This results in an unusual putative topology for ...
Genome features and synteny We identified 18,777 gene families from the homologous protein sequences of Asiatic mouflon and six other species (i.e., sheep, goat, cattle, pig, horse, and mouse). Most (71–81%) of the gene families were single-copy genes (Additional file1: Fig. S1B)....
Moreover, GPBAR undertakes an atypical mode of activation and G protein coupling that features a different set of key residues connecting the ligand-binding pocket to the Gs-coupling site, and a specific interaction motif that is localized in intracellular loop 3. Overall, our study not only ...
Detailed features are zoomed-in in b–e. b The LGD contains fifteen β-strands. The hydrogen bonds between the side chains of Arg71 and Arg98 of the LGD and the main-chain hydroxyl groups of CCP2 are colored red. Phe1257 inserts into a hydrophobic pocket of LGD. c The PD is ...