Proteins are the key molecules of the cell that are involved in all cellular processes. The three-dimensional (3D) shape of a protein provides critical information that can, among many things, be used to study protein interactions, functions and the impact of missense variation. Although tremendou...
TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6 inhibitors are needed for the treatment of a broad range of diseases associated with disturbed calcium homeostasis, including cancers. Here we combine cryo-EM, calcium i
The structure of Pro-CTSC and the Process, maturation, and crystal structure of cathepsin CTSC.AThe structure of Pro-CTSC is defined by distinct domains including the exclusion domain, the propeptide, and the papain-like structure region, encompassing both the heavy chain and the light chain. The...
The IR spectra show changes of specific absorption features caused by varying ratios of Type-I-collagen (T1C) and chondroitin sulphate (CS). The secondary axis of ordinate pertains to the pure IR spectrum of CS (in green). Amide-I-band: A-I, yellow; amide–II–band: A-II, blue; ...
MltD exhibits both endolytic and exolytic reactions in the turnover of the cell-wall peptidoglycan and tolerates the presence or absence of stem peptides in its substrates. The present study reveals structural features of the multimodular MltD, presenting a catalytic module and four cell-wall-...
The curve's features can explain many anatomical facts, including the ball-and-socket ankle, joint alignment in the valgus-varus sense, hip dislocations in spasticity, different epiphyseal heights, short bones in paralysed limbs, long bone overgrowth after fractures, why some joint surfaces remain ...
Interrogation of Linear/nonlinear Features of Guided Waves for Characterizing Hypervelocity Impact-induced Pitting Damage in Shielding Structures MENGLONG LIU, CLIFF J. LISSENDEN, QIANG WANG, ZHONGQING SU, QINGMING ZHANG, RENRONG LONG, FANGSEN CUI PDF SPECIAL SESSION: MULTIFUNCTIONAL MATERIALS AND ...
-weighted imaging (SWI). Collection and evaluation of past situation reports of CFE disclosed usage of SWI in less than 1 / 3rd of suspected situations, despite its recognized diagnostic capability for CFE.This research aimed to characterize the medical featuresimmune stimulation, developmental ...
Collagen I is the most widely occurring type, being the major extracellular constituent of skin, bone, tendons, cornea, lung, heart and blood vessels. Though this collagen mostly occurs as a heterotrimer with two α1(I) chains and one α2(I) chain, small amounts of a homotrimeric form ...
Thus, the collective effect from all layers determines the spectral features of the sample. Dynamic tuning of the optical properties Stretching induces change in interparticle gaps along the stretching direction. We examined Ga nanoparticle interaction in a single layer to understand optical properties ...