In our earlier study, the double-barrel structural feature of OTOP led us to hypothesize that the two α-barrels within each subunit could both function as the proton-conducting pathway as each enclosed a cavity that is exposed to the extracellular side. However, the cavities in both barrels ...
Eight embryos are shown within the uterus of an adult worm at low magnification. Stages seen include pronuclear rotation in the zygote (far left), mitosis in the first cell division (far right), interphase in the two-cell stage (second from left), and various stages of early embryonic ...
UterusGenitalia FemaleGenitaliaOne important feature of muscle structure and function that has remained relatively obscure is the mechanism that regulates thin filament length. Filament length is an important aspect of muscle function as force production is proportional to the amount of overlap between ...
Placental mammals belong to the clade Eutheria and are characterized by fetuses which remain in the uterus of the mother and are nourished by the placenta until a comparatively late stage of neonatal development. In contrast, marsupial offspring undergo a brief uterine gestation followed by a ...
Pregnant mothers at 12.5, 13.5, and 18 days of gestation were euthanized by cervical dislocation, and embryos were immediately removed from the uterus and transferred to 1× 0.1% phosphate buffered saline on ice. Whole embryonic heads were fixed in 4% paraformaldehyde, made up in PB for 2 h...
1998). Hence, the formation of helix-capping interactions may be a general feature of coactivator recognition by NRs. The hydrophobic face of the NR box helix is formed by the side chains of the three motif leucines and the isoleucine preceding the motif (Ile-689). The functional importance...
the relative importance of which depends on cellular and promoter contexts. Both ERs are widely expressed throughout the body, but present different tissue distributions and functions18,19. ERα is primarily expressed in the uterus, liver, kidney, and heart, whereas ERβ is expressed primarily in...
& Wray, S. Drugs acting on the pregnant uterus. Obstet Gynaecol Reprod Med 20, 241–247 (2010). 7. Hagstrom-Toft, E., Enoksson, S., Moberg, E., Bolinder, J. & Arner, P. beta-Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo. Am J Physiol 275,...
By using an antiserum to all molecular weight components of the UfAP, it was shown that these glycoproteins were localized in the glandular epithelium of the uterus. Amino acid sequence analysis of the higher molecular weight (Mr = 47,000-50,000) form indicated it had a common amino-...
The feature vector is generally defined in a way that it is approximately Gaussian distributed with zero mean in the reference (undamaged) state and non-zero mean in the damaged state, hence the designation of the residual vector [57,58]. Many residuals have been used in the literature [59...