The precipitate was recovered by filtration and washed with a few drops of a 6:4 solution of cyclohexane/EtOAc to yield the desired product. Starting compound: methyl 5-(3-(methylsulfonyl)phenyl)furan-2-carboxylate (9). Yield: 88 %. Aspect: greyish solid. mp: 226 °C. TLC (DCM/MeOH...
Fig. 5. Schematic diagram of the MELK inhibitor core structure. (A) 1H-benzo[f]indole core structure of MELK inhibitor; (B) 1H-pyrrolo [2,3-b]pyridine core structure of MELK inhibitor; (C) 4-(8-(cyclohexylamino)− 1,5-naphthyridin-2-yl)phenol core structure of MELK inhibitor. ...
The molecules of 17 self-assemble to form an orga- nogel in cyclohexane. The PXRD spectrum of the gel suggested © 2021 The Author(s). Published by the Royal Society of Chemistry Chem. Sci., 2021, 12, 5361–5380 | 5365 Chemical Science Perspective Fig. 5 (a) Che...
The bifurcation of α and β relaxation times usually intervene in a narrow frequency/temperature range defining a distinct region in the Arrhenius diagram above Tg, typically called crossover region, where a change in the temperature behavior of τα may also be found. More complex situations, ...