One such example is a proposed interaction between PIP2 and positively charged residues in the cytoplasmic carboxy-terminal tail19; another is a putative site between neighboring subunits of TRPM8, where PIP2 binding may enhance channel activity20. The structural details and consequences of ...
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Figure 2. Details of the 351 reductase domain structure. A, features of the 351-PCP–R N-terminal subdomain (N-terminal reductase [R] subdomain—blue, C-terminal R subdomain—cyan, and PCP domain—red). The β-sheet in the cofactor-binding Rossmann fold is shown in magenta, active-sit...
4027 Accesses 7 Altmetric Metrics details Abstract Histamine is a biogenic amine that is critical in various physiological and pathophysiological processes, including but not limited to allergic reactions, wakefulness, gastric acid secretion and neurotransmission. Here, we determine 9 cryo-electron microscopy...
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In this report we describe the structures of the free and testosterone-bound form of the recombinant (3-C4F5) Fab at 2.72 and 2.60 Å, respectively. On the basis of the structures, we are able to describe the details of the testosterone binding and also interpret previous results obtained...
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Structural details of nonstop stalled ribosome recognition. The middle domain of Dom34 is tightly packed against Hbs1 and not involved in ribosomal binding. In contrast to its paralogue eRF1, domain M of Dom34 does not contain a GGQ motif; hence, no catalytic activity is known. Besides ...
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