(e) Non-axial SYCP1 foci frequencies in asynapsed pachytene Syce3Δ/Δ and Syce3WY/WY spermatocytes. *, p < 0.05 (Mann-Whitney U test, medians are 86 and 66 foci, n = 25, 26 nuclei); 3 animals analysed for each Syce3 genotype. Source data Extended Data Fig. 8 SYCE3...
Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. J. Cell Sci. 118, 2755–2762 (2005). Article PubMed CAS Google Scholar Gómez-H, L. et al. C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse ...
In fact, the contribution of abundant hippocampal Lewy neurites to dementia was appreciated well before the discovery that α-syn was the primary constituent of Lewy pathology [14]. Presynaptic aggregates of α-syn in the cortex of DLB patients correspond to reduced dendritic spines, suggesting ...
It has been recently shown that the chemorepulsive axon guidance protein semaphorin3A (Sema3A) is also a constituent of PNNs, binding with high affinity to the sugar chains of chondroitin sulfate proteoglycans. To elucidate whether the expression of Sema3A is modified in parallel with structural ...
crystal structure revealed that TM1 is the main constituent of the pore [15] (Fig.1). The structure also showed that the TM2 lines the pore but in a minor extent, whereas TM3 and TM4 face the hydrophobic membrane environment. The TM1 is tilted, which narrow the pore diameter to 14 ...
Amyloid fibril aggregation is an integral pathogenic constituent behind Alzheimer’s disorder (AD). Drawbacks in current AD medication warrant a searc
It has been recently shown that the chemorepulsive axon guidance protein semaphorin3A (Sema3A) is also a constituent of PNNs, binding with high affinity to the sugar chains of chondroitin sulfate proteoglycans. To elucidate whether the expression of Sema3A is modified in parallel with structural ...
We found that enrichment pathways of the PLS1− gene list contained six of seven pathways of genes from GWAS studies. The enrichment pathways included “cognition”, “Ras protein signal transduction”, “regulation of ion transport”, “synaptic signaling”, “synapse organization”, and “...
it is likely that the proportional relationship between exonic sequence and expression effect is at least in part due to the use of constituent gene products and future use of isoform level expression should provide more specificity of SV effect. We also leverage assumptions about the direction of...
The higher refractive index for NaNbO3than that for NaTaO3suggests that the photons are more retarded, resulting from the electronic polarization while traveling through the medium of the former. The degree of electronic polarization depends upon the size of the constituent atoms of material: the Ta...