Actin is one of the most abundant and highly conserved proteins in eukaryotes that serves as the fundamental structural component of the cytoskeleton [[1-4]]. The actin cytoskeleton is a highly adaptive network of filaments that provides structure and support to cells and enables them to interface...
Dubbed as the fourth component of the cytoskeleton, septins comprise a network of nonpolar hetero-polymeric filaments, which assemble in a guanosine nucleotide-dependent manner. Septins are structurally and functionally interdependent with cell membranes, microtubules, and actin microfilaments. The primary ...
The ciliary rootlet, first recognized over a century ago, is a prominent structure originating from the basal body at the proximal end of a cilium. Despite being the largest cytoskeleton, its structural composition has remained unknown. Here, we report a novel 220-kD protein, designated rootletin...
A Genetic Analysis of Interactions with Spc110p Reveals Distinct Functions of Spc97p and Spc98p, Components of the Yeast γ-Tubulin Complex The spindle pole body (SPB) in functions as the microtubule-organizing center. Spc110p is an essential structural component of the SPB and spans between ...
Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex J. Mol. Biol., 390 (2009), pp. 530-537 View PDFView articleView in ScopusGoogle Scholar 35 F. Gotz, Y. Roske, M.S. Schulz, K. Autenrieth, D. Bertinetti, ...
The fragment of smooth muscle 伪-actinin, comprising the four spectrin-like structural repeating units, has a high 伪-helix content, similar to that of spe... E Kahana,WB Gratzer - 《Cell Motility & the Cytoskeleton》 被引量: 66发表: 1991年 Cis-acting structural element in 5′ UTR is ...
Although the concept of the cytoskeleton as a cell-shape-determining scaffold is well established, it remains enigmatic how eukaryotic organelles adopt and maintain a specific morphology. The Filamentous Temperature Sensitive Z (FtsZ) protein family, an
A crucial component of this autoinhibitory mechanism is the tripartite CH-L2α1-LIM complex, which interacts with the CCinh domain to maintain a CC conformation that facilitates the CCα1 helix’s binding to the MO domain. The binding of Rab10 to MICAL1 initiates the dissociation of the CH...
Microtubules are fibrous, hollow rods that function primarily to help support and shape thecell. They also function as routes along whichorganellescan move throughout the cytoplasm. Microtubules are typically found in all eukaryotic cells and are a component of the cytoskeleton, as well as cilia an...
Septins belong to a family of guanine nucleotide binding proteins, which were first identified in Saccharomyces cerevisiae as essential for the completion of the cell cycle (1). Septins are filament-forming proteins and considered as a novel component of cytoskeleton (2). Although they are absent ...