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The tissue distribution patterns of SA8 genes inT. stephensoniandA. tenebrosawere examined using several approaches. Differential gene expression analysis utilising previously generated tissue-specific reads for three envenomating structures ofA. tenebrosaand three functional regions ofT. stephensonirevealed di...
The binding free energy was calculated as the difference in free energy between the complex and the sum of free energies for the unliganded pthreotceriynstaanldstlriguacntudr.eT(hPeDcBomIDp:le3tSeNβ6 2A). RFu(rwthiledr,tythpee panrodteinintr-apcreoltleuilnarbvinadriianngtfsr)eweaesnme...
This structural difference between human- and parasite-MIF central channels might form a basis for structure-based drug design against the parasites64. A wider channel size in human MIF and MaMIF (Fig. 2D) indicates that this structure might have a functional significance in vertebrates, which ...
Difference with control is *P<0.05, **P<0.01, ***P<0.001. 3. Discussion Based on sequence similarities, the TGFβ superfamily can be subdivided into three main groups: TGFβ s.s., activins and BMPs. Although these three families have been extensively studied in deuterostomes (see Massag...
By eliminating many of the access and knowledge barriers to solve a protein structure, a much larger number of laboratories can participate in structure solution efforts. The difference between a simple structure solution and a structural genomics project is that of scale as well as purpose. Where...
275, 32383-32386) that a large difference between the proportions of charged ve... K Suhre,JM Claverie - 《Journal of Biological Chemistry》 被引量: 286发表: 2003年 Determinants of protein hyperthermostability: purification and amino acid sequence of rubredoxin from the hyperthermophilic archae...
The paralogous genes, NAC2 and NAC67 were found to have maximum mya values, respectively. They showed maximum difference amongst themselves in all the categories of responsiveness. Responsiveness towards abscisic acid was observed to be absent in NAC67 , but present in NAC2 , while responsiveness...
In addition to differential rates of evolution in toxin classes between the snake lineages, these analyses revealed multiple instances of previously unknown instances of structural and functional convergences. Structural convergences included: the evolution of new cysteines to form heteromeric complexes, ...
The DPA time-points that revealed a significant (≥ 2-fold; p-value < 0.05) difference in transcript abundance are indicated by an asterisk and the fold-change in transcript abundance is shown on the graphs above each indicated time-point. Error bars indicate the standard deviation from three...