在随机分组后的第2周,NT-proBNP降低的患者接受的GRMT剂量最高,其次是NT-proBNP稳定的患者,NT-proBNP增加的患者接受的治疗最少(分别为GRMT目标剂量的88.6%、81.8%和70.4%)。同样,利尿剂的使用也存在分级,NT-proBNP降低的患者接受的利尿...
STRONG-HF研究 《柳叶刀》一项研究“Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial”探讨了关于急性...
Randomized trialAims A high-intensity care (HIC) strategy with rapid guideline-directed medical therapy (GDMT) up-titration and close follow-up visits improved outcomes, compared to usual care (UC), in patients recently hospitalized for acute heart failure (AHF). Hypotension is a major ...
The STRONG-HF trial included individuals who were admitted to the hospital for AHF within 72 hours before screening. To be eligible, individuals were prescribed either: one-half or less of the optimal dose of renin-angiotensin receptor system inhibitors (RASi), no β-blocker...
Observation of a heart rate of <55 bpm in the STRONG-HF trial led to less up-titration of β-blockers. However, it could also be considered as a surrogate parameter for the achievement of adequate β-blockade, with a potential protective role.40 Consistently, achievement of a low heart ra...
Findings In this secondary analysis of the Safety, Tolerability, and Efficacy of Rapid Optimization, Helped by N-Terminal Pro–Brain Natriuretic Peptide Testing of Heart Failure Therapies (STRONG-HF) randomized clinical trial including 515 patients, 2 weeks after discharge, medium- to high-dose GDMT...
《 柳叶刀 》一项研究“Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial”探讨了关于急性心力衰竭指南指导的药物治疗剂量上调的安全性、耐受性和有效性。
Liver function tests in patients receiving high-intensity care after hospital admission for acute heart failure: the STRONG-HF trialdoi:10.1093/eurheartj/ehae666.1219BACKGROUND/INTRODUCTION. Episodes of acute heart failure (AHF) unfavorably affect extra-cardiac organs such as the liver due to altered...
Rethinking diuretics for congestion in acute heart failure: insight from the STRONG-HF trial.doi:10.1097/MEJ.0000000000001151Caillard, AnaisCerlinskaite-Bajore, KamileMebazaa, AlexandreEuropean Journal of Emergency Medicine
The STRONG-HF trial is a recent study showing that rapid up-titration of GDMT before discharge reduces the risk of 180-day all-cause mortality or heart failure rehospitalization. To achieve optimal doses for reduction of rehospitalization and death, more decongestion, and better quality of life...