These results support that sotorasib can be given together with strong CYP3A4 and OATP1B1/3 inhibitors but the co鈥恆dministration of sotorasib and strong CYP3A4 inducers should be avoided.Cardona, PanliDutta, SandeepHouk, BrettClinical Pharmacology in Drug Development...
Concomitant administration of WAKIX with strong CYP2D6 inhibitors increases pitolisant exposure by 2.2-fold. Reduce the dose of WAKIX by half. Concomitant use of WAKIX with strong CYP3A4 inducers decreases exposure of pitolisant by 50%. Dosage adjustments may be required (see full prescribing informa...
Concomitant administration of WAKIX with strong CYP2D6 inhibitors increases pitolisant exposure by 2.2-fold. Reduce the dose of WAKIX by half. Concomitant use of WAKIX with strong CYP3A4 inducers decreases exposure of pitolisant by 50%. Dosage adjustments may be required (see full prescribing informa...
Troost J, Tatami S, Tsuda Y, Mattheus M, Mehlburger L, Wein M, Michel MC. Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin. Br J Clin Pharmacol 2011; 72: 247-56....
In conclusion, ACT‐1004‐1239 is classified as a moderately sensitive CYP3A4 substrate (i.e., increase of AUC ≥2‐ to <5‐fold), and this should be considered in further clinical studies if CYP3A4 inhibitors are concomitantly administered.Huynh, Christine...
In vitro data support involvement of cytochrome P450 (CYP)2C8 and CYP3A4 in the metabolism of the anaplastic lymphoma kinase inhibitor brigatinib. A 3-arm, open-label, randomized, single-dose, fixed-sequence crossover study was conducted to characterize the effects of the strong inhibitors ...
We dispense drugs to haematological outpatients whose treatments can combine alfuzosin (for lower urinary tract symptoms, LUTS) with anti-infective drugs that may be strong CYP 3A4 inhibitors. We conducted a pharmaceutical intervention (PI) but lacked a clear and consensual management for physicians....
In vitro data support involvement of cytochrome P450 (CYP)2C8 and CYP3A4 in the metabolism of the anaplastic lymphoma kinase inhibitor brigatinib. A 3゛rm, open﹍abel, randomized, singleヾose, fixed﹕equence crossover study was conducted to characterize the effects of the strong inhibitors ...
Interruption of mavacamten during short term administration of inhibitors transiently increased VLVOTg for the duration of interruption, with no effect on LVEF.#Conclusion:Coadministration of mavacamten with CYP3A4 or CYP2C19 inhibitors could be accommodated within the titration scheme with dose ...
Concomitant Use of Midostaurin with Strong CYP3A4 Inhibitors: An Analysis from the Ratify Trial - ScienceDirectTaoufik Ouatas PhD *Vincent Duval PharmD *Karen Sinclair PhD *Noah Berkowitz MD PhD *