Definition Chapters and Articles Related Terms Recommended Publications Featured Authors Chapters and Articles You might find these chapters and articles relevant to this topic. Chapter Benign Causes of Bone Marrow Abnormalities Including Infections, Storage Diseases, Systemic Disorders, and Stromal Changes ...
cells present a myofibroblast-like phenotype (myCAF) defined by a high expression of α-SMA, whereas CAFs distant from cancer cells barely express α-SMA but secrete high amounts of inflammatory cytokine IL-6 (iCAF), which contradicts the previous definition of CAFs as α-SMA cells [61]. ...
et al. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11, M111.014647 (2012). 32. Kalluri, R. & Zeisberg, M. Fibroblasts in cancer. Nat. Rev. Cancer 6, 392–401 (2006). 33. Quante, M. ...
much less is known about how the normal stroma exerts tumour-suppressive signals to control tissue homeostasis. Furthermore, the role of epigenetic regulators in the ability of the cells to respond to the stiffness of the tumour microenvironment is not known. To investigate...
TGFβ1 is the most pleiotropic of all known cytokines and thus, to avoid uncontrolled TGFβ-activated processes, its activity is tightly regulated.