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Amantadine hydrochloride has been increasingly prescribed as a neurostimulant for neurocritical care stroke patients to promote wakefulness during inpatient recovery. However, a lack of guidelines makes it difficult to decide who may benefit from this pharmacotherapy and when amantadine should be initiated ...
While some level of spontaneous biological recovery can occur after a stroke, this process is often incomplete, leaving most stroke survivors with persistent gait impairments, which can lead to walking disabilities, falls, and reduced health-related quality of life [3, 4]. As a result, ...
This randomized crossover study examines the effect of targeted high-definition transcranial direct current transcranial brain stimulation (tDCS) on upper extremity motor recovery in patients in the post-acute phase of stroke recovery. Methods This randomized double-blinded cross-over study includes four...
As recovery occurs, the balance in activity (as seen using fMRI) between bilateral hemispheres, returns[37, 41]. We are exploring whether delivering tDCS to PMC in the stroke-affected hemisphere helps restore this balance. Another form of functional neuroimaging, called resting-state fMRI[57], ...
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functional neuro-imaging analysis of post-stroke plasticity will help us to better understand the neuronal networks involved in motor and cognitive recovery. Although researchers have applied the capacity-sharing, bottleneck, and cross-talk theories to CMI and its neural correlates in humans, further ...
MicroglialNhe1cKO mice displayed accelerated post-stroke cognitive function recovery We previously reported thatCx3cr1-CreER+/−;Nhe1f/fmouse line successfully deleted NHE1 protein expression only in IBA1+microglia, but remained intact in other cell types18. WT andNhe1cKO mice underwent ischemic ...
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The aims of this study are thus to (1) investigate the effects of Swiss-ball training, VR training, and their combination on mobility, balance, and cortical activation in individuals with stroke and (2) provide evidence for elucidating the recovery mechanisms of balance and mobility function in...