Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic ...
Some genetic variants identified through GWAS are associated with different aspects of stroke risk, including blood pressure, venous thromboembolism, and lipid metabolism, all of which are relevant to the pathophysiology of stroke [14, 15]. Additionally, GWAS has revealed new loci unrelated to stroke...
Depicts the eicosanoid inflammatory pathway. Genes shown in red contain a SNP associated with worse functional outcome. The COX2 locus contains both risk and protective variants which are detailed in the gray boxes. Abbreviations are as follows: thromboxane A2 (TXA2), prostacyclin (PGI2), prostaglan...
ECG abnormalities after AIS correlate strongly with neurological outcomes. Compared with that in patients with normal QTc, the mortality rate triples in patients with prolonged QTc during the early AIS [18]. AF, atrioventricular block, ST-segment changes, and inverted T-waves increase the mortality ...
The pathophysiology of cerebral ischemic injury is elaborated, and experimental animal models of global and focal ischemic stroke, as well as in vitro stroke models, are illustrated in detail, with the different experimental strategies to analyze the injuries, explained. Finally, we analyse previous ...
The pathophysiology of thrombotic stroke encompasses an ischemic core of irreversibly damaged brain tissue intermixed with marginal penumbra regions with reduced blood flow2. Importantly, the penumbra, although metabolically compromised, is potentially salvageable if the region could both be protected from ...
15 However, given the well-documented importance of sex in the epidemiology and pathophysiology of stroke,16 the possible underenrollment of women in these and other stroke trials represents a threat to their generalizability and in turn to the validity of the evidence base with regards to the ...
Investigations into the pathophysiology of VaD have revealed that glial activation, WM injury, endothelial dysfunction, and BBB leakage jointly contribute to cognitive decline (Huisa et al., 2015; Lee et al., 2019; Manso et al., 2018; Saggu et al., 2016; Tayler et al., 2021; Yu et al...
Bioinformatic pathway analyses using KOBAS [121] revealed the involvement of several pathways in NVU cells, of which some have been reported to be involved in stroke pathophysiology: HIF-1 signaling pathway in microglia [8] and in endothelial cells, Wnt signaling pathway and PI3K–Akt signaling ...
Characterization of brain infarct lesions in rodent models of stroke is crucial to assess stroke pathophysiology and therapy outcome. Until recently, the analysis of brain lesions was performed using two techniques: (1) histological methods, such as TTC (Triphenyltetrazolium chloride), a time-consuming...