(genome-wide threshold line in red): 5.0 × 10−8. Associations are from fixed-effect meta-analyses based on logistic regression models adjusted for sex and the first ten principal components.Ndiscovery = 68,281 individuals (\(N_{{\mathrm{COPSAC}}_{\mathrm{severe}}}\) = ...
On the other hand, caution should be observed as inhibition of particular CBPs may induce undesirable side effects, such as the increase of tolerance to antibiotics when LytA is inhibited [96,232] or the inability of cure of infection. Nevertheless, it is expected that the numerous detrimental...
In contrast to the infection with the capsular polysaccharide-deficient strain 10∆cpsEF which was not able to colonize the nasopharyngeal cavity, we observed effective colonization of the murine nasopharynx by wild-type strain 10 (in nine of 10 mice) and strain 10∆flpS Pathogens 2016, 5,...
International Journal of Molecular Sciences Article Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae Miriam García-López 1 , Pablo Hernández 2, Diego Megias 3, María-José Ferrándiz 1,* and Adela G. de la ...
Dental caries, as a multi-factorial infection, is the most common and prevalent chronic oral disease in childhood and is considered a serious worldwide public health problem [1]. Streptococcus mutans (S. mutans) has been considered the principal oral pathogen involved in the development of dental...