The use of NGS was found to be more effective than conventional testing in identifying patients with adverse risk, with a hazard ratio for death of 0.22 (95% CI, 0.08989-0.5732) compared to a hazard ratio of 0.66 (95% CI, 0.4352 -1.031) for conventional PCR testing. Conclusion In this ...
Finally, when modeling age-specific risk we used the hazard ratio estimated for the closest age quartile for ages less than the first age quartile and greater than the fourth age quartile (see “Methods”). Through this approach, we did not estimate exact hazard ratios (HRs) outside of the...
CI = confidence interval; HR = hazard ratio; PSADT = prostate-specific antigen doubling time. At the final analysis, darolutamide significantly prolonged OS versus placebo in both PSADT subgroups (Fig. 1). The risk of death was reduced by 45% in the PSADT >6 mo subgroup (p = 0.01) ...
Figure1depicts the incidence rates and hazard ratios (HRs) of each of the disease outcomes for each patient group by initial disease severity sub-grouped by age. In general, in the acute phase of infection, patients classified as mild–moderate severity were associated with the lowest risk of ...
(hazard ratio [HR] 0.70, 95% CI: 0.66–0.74), and a 41% reduction in breast cancer mortality (95% CI: 27–52%) when adjusting for propensity score and year of birth [79]. Compared to clinical examination, the overdiagnosis with risk-based screening was negligible (HR for diagnosis ...
*Indicates overall p-value for the categorical variable calculated using the likelihood ratio test. 1.98 Odds of death§ 95% CI 0.71 – 1.33 1.06 – 2.30 1.66 – 4.72 0.28 – 1.24 0.31 – 1.20 0.29 – 1.32 0.82 – 2.13 0.74 – 2.23 0.97 – 2.37 0.90 – 2.29 1.38 – 2.83 p-value ...
The primary efficacy parameter is the odds ratio comparing FEVAR to both open repair and off label EVAR. For OSA, conservative 57 estimate of 8% peri-operative death might be expected, and a reduction to 4 % could be 58 considered clinically relevant, which is equivalent to an odds ratio...
Although BRAF and KRAS G12C mutations were not at a greater incidence in comparison to the rest of North America, they were notably significant predictors of survival, conferring nearly 3.4 and 2.7 times increased risk of death in our study.VariableHazard RatioSELower 95 CIUpper 95 CIzp-value...
This improved prognosis was validated in an independent cohort of 77 oral cavity cancers and a meta-analysis that included two additional datasets (688 total patients, hazard ratio for death 0.44, 95% CI 0.30-0.65). NSD1 mutations are more common in HPV-negative heavy smokers and define a ...
Univariable Cox regression testing revealed that preserved SBP patients had a higher risk of a composite of cardiac death and heart failure re‐hospitalization [hazard ratio (HR) 1.48, 95% confidence interval (CI) 1.14–1.92, P = 0.0035] than elevated SBP patients. In multivariable Cox ...