Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy has become a game-changing therapeutic approach revolutionizing the treatment setting of human malignancies, such as renal cell carcinoma (RCC). Despite the remarkable clinical
The iterated prisoner’s dilemma has been used to study human cooperation for decades. The recent discovery of extortion and generous strategies renewed interest on the role of strategy in shaping behavior in this dilemma. But what if players could perceive each other’s emotional expressions? Despi...
At the same time, we recognize several constraints of our OTTO approach as currently implemented: (i) The biological significance of most SNPs derived from GWAS is not yet clear. Many SNPs are intergenic or intronic and thus still lack any viable path to mechanistic insight. (ii) The GRAS ...
A clear framework guides the reader through the four parts of the book, covering: *an introduction to logistics and its contribution to competitiveness and value creation, *leveraging logistics operations within the context of the customer, *supplier partnerships, interfaces and the challenges of ...
However, according to the list-based query responses, only ca 2% of the participants reported using no strategy in the final task block. Although this particular discrepancy largely reflects non-responding on the open-ended queries, it also applies to some extent to the other types of strategies...
According to the functional unit chosen (1 t of tuna entering the canning industry), no allocation procedure was required. This system is a clear example of system expansion, following the guidelines set out in the ISO standards for dealing with multi-product systems. However, the use of ...
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Solved: Hello Gurus, I am new to SAP PP. Can any one explain me the importance of Strategy Group maintained in MRP 3 View of Material Master. Please explain in lay man's
In our previous study, ETV5 mediated-angiogenesis was demonstrated to be dependent upon the PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC). However, the ability of ETV5 to affect the efficacy of anti-angiogenic therapy in CRC require
a single substituent may be introduced at the desired α carbon. This is difficult to achieve starting from ketones with no clear electronic or steric bias (Fig.1b). This approach has been successful, but it relies on the use of heteroatomic electrophiles. These are highly reactive species,...