ExosomesIsolationExtracellular vesicles (EVs) are a family of cell-derived membrane vesicles that are present in almost all body fluids. EVs have gained significant interest over the last decades as mediators of key functions in numerous patho-physiological condition (clearance, signalling, trophic ...
Exosomes, which are nanoscale vesicles secreted by almost all cell types via paracrine pathways, play a crucial role in intercellular communication. For nearly a decade, exosomes have been widely exploited to develop novel biologic therapeutic strategies for recalcitrant clinical problems such as chronic...
Here, we review the transport pathways across the BBB, as well as various types of LBNs for AD therapy, including exosomes, liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), to elucidate their distinctive properties, preparation methodologies, and therapeutic ...
The ultimate goal of nanomedicine is the precise and targeted delivery of drugs to desired cells while avoiding harm to healthy tissues. The cargo-carrying capacity and selectivity of exosomes can be improved for greater therapeutic effects using various modified exosomal production technologies through c...
Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling. Analyst. 2016;141:4640–6. 42. Niu Z, Pang RTK, Liu W, Li Q, Cheng R, Yeung WSB. Polymer-based precipitation preserves biological activities of extracellular vesicles from an ...
Mesenchymal stem cells (MSCs) are one of the elements of the tumor microenvironment (TME) which plays a key role in primary tumor growth and metastasis. For example, exosomes secreted by MSC-differentiated adipocytes have been proposed that can promote EMT in breast cancer cells via activation of...
thereby influencing the process of bone remodeling and repair.76Recent studies have increasingly supported the hypothesis that bone-derived exosomes can affect the brain. The exosomal membrane allows them to cross the BBB, providing a structural basis for using exosomes to treat brain diseases.77Additi...
Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communication are created via exosomes in the tumor micro
Here, we review the transport pathways across the BBB, as well as various types of LBNs for AD therapy, including exosomes, liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), to elucidate their distinctive properties, preparation methodologies, and therapeutic ...
exosomes mainly depends on the functional state of the parent cells. The analysis of changes in the content and composition of exosomes in the body fluids can reflect the state of the parent cells, which can provide a basis for the diagnosis of the oral and maxillofacial diseases and even ...