HIV治愈会议Strategies for an HIV Cure第一天的重点还是之前的三个最重要的方向:1. 寻找HIV治愈的标记物;2. 寻找好的储藏库激活剂;3. 寻找杀死储藏库细胞的方法。 1. 停药后病毒不反弹是治愈的金标准。MHRP...
The purpose was to bring together researchers studying HIV persistence and cure strategies, including the six National Institutes of Health (NIH)-funded Martin Delaney Collaboratories for HIV Cure Research (MDCs), as well as industry and community partners, to share scientific results and stimulate ...
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its com
Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide. Reservoirs are infected cells that can maintain HIV persistence for several years in patients with optimal cART, which is a...
nanocarriers in anti-HIVnanoparticlesvaccinesnanoprobesIt is a hard work to develop an hightly effective cure and prevention of HIV/AIDS. The widespread used of some therapy approaches such as highly active anti retroviral therapy (HAART) has improved life quality and span of infected individuals. ...
Despite the success of highly active antiretroviral therapy (HAART) for inhibiting HIV replication and improving clinical outcomes, it fails to cure infection due to the existence of a stable latent proviral reservoir in memory CD4+ T ce... JT Kimata,AP Rice,W Jin - 《Current Opinion in Immu...
Box 1 Measuring the latent reservoir of HIV-1 Accurately determining the size of the latent reservoir of HIV-1 is essential for assessing the effectiveness of novel strategies for HIV-1 cure, and the way in which reservoir size is measured is highly relevant to the interpretation of results; ...
The majority of virally suppressed individuals will experience rapid viral rebound upon antiretroviral therapy (ART) interruption, providing a strong rationale for the development of cure strategies. Moreover, despite ART virological control, HIV infecti
PURPOSE OF REVIEW: To review current knowledge of viral reservoirs in the central nervous system (CNS) and identify the CNS-specific barriers and strategies to cure human immunodeficiency virus type 1 (HIV-1) within the brain. RECENT FINDINGS: The cumulative data of HIV-1 infection of the CNS...
Achieving a cure for human immunodeficiency virus (HIV)-1 must first clear the obstacle posed by long-lived cellular reservoirs of the virus. Clearing this obstacle will require a fuller understanding of the nature of the reservoirs in which HIV-1 is able to persist as well as practical strat...