doi:10.1056/NEJMoa042991PubMedGoogle ScholarCrossref 5. Mayer SA, Brun NC, Begtrup K, et al; FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008;358(20):2127-2137. doi:10.1056/NEJMoa0707534PubMedGoogle ...
There as a landmark study called KANON (Knee Anterior cruciate ligament NON operative vs operative treatment) published over a decade ago (NEJM 2010). KANON was an RCT of 121 young active adults with an acute ACL injury. The primary outcome was the change from baseline to two years in the...
It must be assumed that only a small proportion of all bony injuries to the pelvis with mechanical instability of the pelvic ring are complex pelvic ring injuries which are associated with relevant bleeding and benefit from non-invasive pelvic stabilisation. In a review of the literature, Gänss...
According to a 12-month study published in the New England Journal of Medicine (NEJM), 66% of Inspire patients saw a reduction of AHI events by 50% or more, indicating a strong improvement in breathing quality. 75% of patients on Inspire also experienced a reduction of their Oxygen Desatura...
doi:10.1056/NEJMoa011795PubMedGoogle ScholarCrossref 18. Flinn IW, van der Jagt R, Kahl BS, et al. Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood. 2014;123(19):2944-2952. doi:10.1182...
It may be difficult to perform a trial in which all participants randomized to e-cigarette only used this and no other methods (e.g., behavioral therapy, pharmacotherapy) and where the control group only used what was assigned to them, but it is important to note that any other co-interve...
After marketing, there were several studies done that looked at the effect of vaccination on household transmission of SARS-CoV-2. One suchstudy,published in the NEJM, showed that overall the likelihood of household transmission was 40-50% lower in households of index patients who had been vacci...
2007; 356: 1503-1516https://doi.org/10.1056/NEJMoa070829 Crossref PubMed Scopus (3162) Google Scholar , Al-Lamee R Thompson D Dehbi H-M et al. Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.Lancet. 2018; 391: 31-40https://doi...
No validation of self-reported smoking status will be undertaken in this trial. Study participants will be located throughout New Zealand (a country of approximately 1,600 km in length) and for budgetary and logistical reasons it is not possible to conduct face-to-face verification of their smo...
Coleman T, Cooper S, Thornton JG, Grainge MJ, Watts K, Britton J, Lewis S: A randomized trial of nicotine-replacement therapy patches in pregnancy. N Engl J Med. 2012, 366 (9): 808-818. 10.1056/NEJMoa1109582. Article CAS PubMed Google Scholar Oncken C, Dornelas E, Greene J, Sank...