肿瘤坏死因子是一种重要的炎性细胞因子,目前已知许多免疫疾病与之相关,为了抑制TNF的生物学活性,将可溶性TNFR Ⅱ(sTNFR Ⅱ)和人IgG Fc分子通过柔性短肽相连,构建成一个嵌合蛋白,在大肠杆菌中进行表达,并获得了纯化蛋白.实验证明该嵌合蛋白能够自发形成聚合体,识别并结合TNF蛋白,同单体sTNFR Ⅱ相比,对TNF的中和活性...
Ex vivo production of TNF-α at different levels of LPS stimulation and plasma concentrations of TNF-α and soluble TNF receptors (sTNFr-I&II) as potential indicators of TNF production in AIDS patients: R. Heijligenberg 1,2,3, J.A. Romijn 1,2,4, E. Endert ...
levels of sTNFR-II, together with the concurrent hyperactivation of AMPK signaling contribute to reduced production of leptin in ALS-affected adipocytes. Many lines of evidence support this conclusion: (i) cultured human adipocytes released less leptin when conditioned with plasma from fast ALS; (ii...
功率小说明物体做功少 C. 机器做功越多,其功率越大 D. 机器做功越快,其功率越大 **答案**: [答案]D [点拨]功率反映做功的快慢,不能反映做功多少,功率大时,做功不一定多。 ©2024 Baidu |由 百度智能云 提供计算服务 | ...
百度试题 结果1 题目de yin jié shi3.“走”的音节是liang pin yin jieA.两拼音节stnpinyt=iieB.三拼音节 相关知识点: 试题来源: 解析 3.A 反馈 收藏
Distinct Plasma Immune Profile in ALS Implicates sTNFR-II in pAMPK/Leptin HomeostasisLEPTINLEPTIN receptorsTUMOR necrosis factor receptorsAMYOTROPHIC lateral sclerosisHOMEOSTASISAMP-activated protein kinasesPROTEIN kinasesAmyotrophic lateral sclerosis (ALS) is a clinically highly heterogeneous d...
sTNFr-II and age at infection were independently associated with the minimal injury case group. When sTNFr-II was excluded from the logistic regression model, sFas and age at infection were independently associated with the case group. CONCLUSION: The rate of progression of parenterally acquired ...
Effect of acupuncture-moxibustion on TNF-α, sTNFR-I and sTNFR-II of rats with Crohn’s disease[J] . Zheng Shi,Xiao-peng Ma,Huan-gan Wu,Xiu-di Qin,Qing-lan Qian,Wei Zhang.Journal of Acupuncture and Tuina Science . 2009 (1)
Clinical evaluation of proinflammatory cytokine inhibitors (sTNFR I, sTNFR II, IL-1 ra), anti- inflammatory cytokines (IL-10, IL-13) and activation of neutrophils after burn-induced inflammation. Scand J Immunol. 2008; 68:145-152. [PubMed: 18702744]...
Cloning, Expression and Bio-activity Assay of Chimeric Fusion Protein sTNFRII-IgG Fc嵌合蛋白sTNFR II-IgG Fc的克隆、表达与活性分析可溶性肿瘤坏死因子受体嵌合蛋白大肠杆菌生物学活性Tumor necrosis factor (TNF) is a key cytokine in immunology system and is related to many human diseases. In order to...