干扰素基因刺激因子|Stimulator of Interferon Genes STING(干扰素基因刺激因子)是一种定位于内质网的跨膜蛋白,在环二核苷酸(CDN)的直接结合下发生构象变化,导致下游信号级联,涉及TBK1激活、IRF-3磷酸化和IFN-β及其他细胞因子的产生。 STING是一种环状二核苷酸的模式识别受体,也是一种天然的免疫衔接蛋白,能够从细胞质...
上次与大家分享了干扰素基因刺激因子(stimulator of interferon genes, STING)的在肿瘤方面的相关研究及生信分析的新方向。 概普生信:Nature新热点分享:干扰素刺激因子(STING)那么两年连登Nature的STING有何魅…
Recently, the stimulator of interferon genes (STING) pathway and type I interferons, its downstream molecules, have been reported to be involved in the neurodegenerative process and to be activated in astrocytes. This study aimed to investigate the role of the STING pathway in the pathogenesis of...
genes of this family. All type I IFNs interact with a single heterodimeric receptor composed of two subunits,interferon alphaand betareceptor subunit(IFNAR)1 and IFNAR2. This receptor is ubiquitously expressed, and binding of its ligand induces – via theJanus kinase(JAK)–STAT (signal ...
Detection of cytoplasmic DNA by the host’s innate immune system is essential for microbial and endogenous pathogen recognition. In mammalian cells, an important sensor is the stimulator of interferon genes (STING) protein, which upon activation by bacterially-derived cyclic dinucleotides (cDNs) or ...
中文名称: D61|||STIMULATOR OF INTERFERON GENES AGONIST D61 中文同义词: D61|||STIMULATOR OF INTERFERON GENES AGONIST D61;化合物 STING AGONIST D61 英文名称: STING Agonist D61 英文同义词: STING Agonist D61 CAS号: 2850251-27-1 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏...
Provided herein are Stimulator of Interferon Genes (STING) ligand for use in enhancing immune response and/or as adjuvants in vaccines. In some embodiments, STING ligand is used alone or in combination with Alum in an adjuventation system for early life immunization.Ofer Levy...
STIMULATOR OF INTERFERON GENES AGONISTSStimulator of Interferon Genes (STING) modulators and their use for treating a disease, disorder, or condition associated with STING.
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-...