干扰素基因刺激因子|Stimulator of Interferon Genes STING(干扰素基因刺激因子)是一种定位于内质网的跨膜蛋白,在环二核苷酸(CDN)的直接结合下发生构象变化,导致下游信号级联,涉及TBK1激活、IRF-3磷酸化和IFN-β及其他细胞因子的产生。 STING是一种环状二核苷酸的模式识别受体,也是一种天然的免疫衔接蛋白,能够从细胞质...
上次与大家分享了干扰素基因刺激因子(stimulator of interferon genes, STING)的在肿瘤方面的相关研究及生信分析的新方向。 概普生信:Nature新热点分享:干扰素刺激因子(STING)67 赞同 · 10 评论文章 那么两年连登Nature的STING有何魅力?接下来跟大家分享一下STING在相关疾病中的研究进展。 在整个进化过程中,从原核生物...
单基因干扰素病强调了STING及其下游途径的致病潜力。研究表明，干扰素相关的疾病是由核酸代谢相关基因的多种突变引起的。这些研究证实，慢性激活STING以维持干扰素相关疾病和全身性自身免疫疾病典型的高干扰素状态。在肾脏疾病方面，cGAS-STING通路可能导致急性肾损伤（AKI）和慢性肾脏病（CKD）。肾毒性剂顺铂刺激...
Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase 41 (DDX41), and interferon-γ-inducible protein 16 (IFI16). The activation of STING signaling leads to the ...
Stimulator of Interferon genes (STING) acts as a cytosolic DNA sensor as well as an adaptor molecule for type I interferon signaling. STING is also an important regulator of paracrine inflammatory responses, effectively functioning as a "signaling hub" molecule. Our current data shows that primary...
Detection of cytoplasmic DNA by the host’s innate immune system is essential for microbial and endogenous pathogen recognition. In mammalian cells, an important sensor is the stimulator of interferon genes (STING) protein, which upon activation by bacterially-derived cyclic dinucleotides (cDNs) or ...
Stimulator of interferon genes (STING) as a therapeutic target for atrophic age-related macular degeneration Purpose : In age-related macular degeneration (AMD), inflammation is a major factor in disease progression. We and others have shown that inflammasome activation through the upregulation of ...
virus stimulator of interferon genes (STING) cyclic GMP-AMP (cGAMP) caspase-8-like (Casp8L) NF-kappaB antiviral Introduction Over recent decades, the innate immune responses elicited by nucleic acids derived from viruses, bacteria, or protozoan parasites have been intensively studied in mammals (1...
中文名称:D61|||STIMULATOR OF INTERFERON GENES AGONIST D61 中文同义词:D61|||STIMULATOR OF INTERFERON GENES AGONIST D61;化合物 STING AGONIST D61 英文名称:STING Agonist D61 英文同义词:STING Agonist D61 CAS号:2850251-27-1 分子式: 分子量:0 ...