Exposure of hypertrophied myocytes to the Orai channel blocker BTP2 caused a reduction of AP duration and reduced diastolic Ca 2+ spark rate. BTP2 had no effect on normal myocytes. Forced expression of STIM1 in cultured adult feline... CD Troupes,M Wallner,G Borghetti,... - 《Circulation...
MultiStim: Programmable 8-Channel Stimulus Generator Model 3800 Each of the 8 Completely Independent Channels Can Deliver Pulse durations as short as 1 µs over a 15 minute timing interval Up to 1 µs with a 250-hour timing interval In addition to monophasic and biphasic pulse trains, ...
STIM1TRPC1Neurotransmitter regulation of salivary fluid secretion is mediated by activation of Ca2+ influx. The Ca2+-permeable transient receptor potential canonical 1 (TRPC1) channel is crucial for fluid secretion. However, the mechanism(s) involved in channel assembly and regulation are not ...
The junctional coupling between endoplasmic reticulum (ER) Ca2+-sensor STIM proteins and plasma membrane (PM) Orai channels is a universal Ca2+<Baraniak, Jr, James H.Zhou, YandongNwonkonko, Robert M.Jennette, Michelle R.Kazzaz, Sarah A....
Two decades of intense research together with technology advances uncovered the identity of the main components of SOCE, the endoplasmic reticulum (ER) Ca2 + sensor, STIM1 [6], [7], and the plasma membrane Ca2+ channel regulated by intracellular Ca2+ store depletion, Orai1 [8], [9], [...
aSTIM module include one Meta-TEDS,two Channel-TEDS which used to store temperature data and input signal of PH sensor,one Calibration-TEDS and one Meta-ID TEDS.the basic design of TEDS is shown in Tab 1 STIM模块包括一阶TEDS,二曾经存放温度数据和酸碱度传感器输入信号的渠道TEDS,一定标TEDS,...
Canonical transient receptor potential-1 (TRPC1) is an almost ubiquitously expressed channel that plays a relevant role in cell function. As other TRPC members, TRPC1 forms receptor-operated cation channels that exhibit both STIM1-dependent and store-independent behaviour. The STIM1 inhibitor SARAF ...
RNAi screening approaches identified two proteins, Stim1,2and Orai3-5, that together form the molecular basis for CRAC channel activity6,7. Stim senses depletion of the ER Ca2+store and physically relays this information by translocating from the ER to junctions adjacent to the plasma membrane ...
The ubiquitously expressed Orai Ca2+ channels are gated through a unique process of intermembrane coupling with the Ca2+-sensing STIM proteins. Despite the significance of Orai1-mediated Ca2+ signals, how gating of Orai1 is triggered by STIM1 remains unk
Οκαιρός σήμερασε Stimlje Αίσθησηθερμοκρασίας-4° 06:44 16:56 Υψηλή / Χαμηλή 6°/-5° Άνεμος 3 χλμ/ώρα Υγρασία 80% Σημείο δρόσου -7° Πίεση 1033.2 mb Δ...