that the remainingcyp19a1aexpression inbmp15−/−zebrafish mutants is located in thecal cells, which may have aggregated in the gland-like structures found in the GCF ovaries. Expression oflhbin female pituitaries did not differ between any groups (Fig.5b), which suggests that there is no ...
Steroid hormone signaling starts with the synthesis and secretion of the hormones into the extracellular space by the signaling cell. In vertebrates, both fetus and postnatal, the hormone is carried through the bloodstream bound by proteins that prevent its degradation and increase its solubility in...
The purified proteins had molecular weights of 59,000 and 57,000, but amino acid compositions and N-terminal sequences, when compared with the four mammalian CYP1α sequences that are now known, make it unlikely that either of these proteins was indeed the 1α-hydroxylase cytochrome P450. ...
in short, is the branch of biology that deals with the functions and activities of living organisms. More specifically, it concerns the organs, tissues and cells, as well as the chemical reactions between them. Believe me; you don’t want...
S1a). Expression of the protein starts in the intestinal cells in late L2d worms (i.e. the specific L2 larval stage that precedes the dauer larva), about 44 h after hatching at 25 °C (Fig. S1b). During dauer formation, fluorescence in the gut lumen increases (Fig. S1c). ...
Kim et al. further demonstrated that such apop- totic activation can be Bcl-2, Bcl-xL or Bax independent [84-87]. In human neuroblastoma (SK-N-BE) and rat gli- oma models, Rh2-induced apoptotic cell death has been implicated via protein kinase C (PKC) and reactive oxy- gen-...
Systemic corticosteroid therapy failure is quite common in patients with newly diagnosed acute graft-versus-host disease (aGVHD). Growing evidence has suggested that mesenchymal stem cell (MSC) therapy could be a promising treatment option for aGVHD due to its distinctive immunomodulating functions. Howe...
Through the surge of news about doping scandals in the media, it is expected that the public is aware of the magnitude of the problem among professional athletes; however, it is uncertain whether the public is aware that the problem often starts when athletes are younger. To this end, the ...
We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to ...
. (e) Percentage of larvae that completed metamorphosisin vitrowithout fungal or sterol inoculation (first bar), with fungus collected directly from brood cells (second bar) and with ergosterol at 2.5 µM added in the larval food (third bar), in three different experiments (N = 48 ...