Steroid hormones are lipophilic compounds derived from cholesterol metabolism, which typically mediate their biological activity by binding to an intracellular cytosolic receptor. Hormone binding to its receptor causes the receptor to translocate to the nucleus where it forms a homodimer with another ligand...
1.Any of numerous fat-soluble organic compounds that have a core structure of 17 carbon atoms arranged in four rings, found naturally in animals, plants, and fungi, or produced synthetically. Steroids include the sterols (such as cholesterol), sex hormones (such as estrogen and testosterone), ...
The fungistatic and genestatic (sporulation-inhibiting) effects of 12 hormones on 14 pathogenic fungi were studied. Oestrogenic hormones exerted a more appreciable genestatic action than androgenic. The most effective fungistatic compound was diethylstilbestrol, the other steroid hormones investigated showin...
1988. Structure–activity relationship of cholesterol and steroid hormones with respect to their effects on the Ca 2+ -stimulated ATPase and lipid fluidity of synaptosomal plasma membranes from dog and rabbit brain. Comp Biochem Physiol B 89: 585–594....
(sequences of chemical transformations in the body), both of synthesis and of decomposition, have become known in considerable detail for most steroids present inmammals, and much research relates to control of these pathways and to the mechanisms by which steroid hormones exert their effects. The...
Steroid hormones are known to exert their biological effects by binding to their intracellular receptors, translocating to the nucleus, and regulating gene transcription. However, steroid hormones have also been shown to exert rapid effects on neuronal excitability by interacting with specific neurotransmitt...
DISTRIBUTION OF SEX STEROID HORMONES AND THEIR RECEPTORS IN THE GONADS AND NERVOUS SYSTEM OF AMPHIOXUS (BRANCHIOSTOMA BELCHERI) 来自 Semantic Scholar 喜欢 0 阅读量: 2319 作者: YQ Fang 摘要: Immunocytochemical localization were investigated for the first time in the gonads, brain vesicle and nerve ...
For this reason, other approaches to causal inference such as Mendelian randomization (MR) can be used to provide evidence for or against the role of sex hormones. MR uses genetic variants that predict changes in exposures (e.g. hormone levels) and assesses their effect on outcome (e.g. ...
There, GnRH causes the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn act upon the gonads to stimulate their maturation, and to cause synthesis of sex steroid hormones, ... Gore,C Andrea - Springer US 被引量: 96发表: 2011年 ...
These myriad effects are mediated by receptor proteins that are specific for each steroid hormone class (estrogens, androgens, progestogens, glucocorticoids, and mineralocorticoids). Although the actions of steroid hormones are broad, their effects are similarly mediated in each tissue through their ...