endocrine signals orchestrate a 30% net increase of absorptive epithelium. Mating increases production of the steroid hormone Ecdysone released by theDrosophilaovaries that stimulates intestinal stem cell (ISC) divisions. Here, we uncover the transcription...
Here we show that the growth and body size response to moderate hypoxia (10% O) inis systemically regulated via the steroid hormone ecdysone. Hypoxia increases level of circulating ecdysone and inhibition of ecdysone synthesis ameliorates the negative effect of low oxygen on growth. We also show ...
Baulieu E-E, Binart N, Cadepond F et al. (1989) Do receptor-associated nuclear proteins explain earliest steps of steroid hormone function? In: Carlstedt-Duke J, Eriksson H, Gustafsson J-Å (eds) The steroid/thyroid hormone receptor family and gene regulation. Birkhäuser, Basel, pp 30...
20E, 20-hydroxecdysone; DMSO, dimethyl sulfoxide; RAPTOR, regulatory-associated protein of TOR. Similarly, the expression levels of Abd-a, Abd-b, and Ubx were reduced during metamorphosis, so we speculated that 20E also inhibited their expression. We performed hormone concentration gradient and ...
We show that the steroid hormone ecdysone functions in Drosophila to control lipid metabolism and support oocyte production. First, local EcR-mediated signaling induces a stage-specific accumulation of lipids in stage-10 oocytes. EcR induces lipid accumulation by promoting the activation of the ...
Every adrenal steroid hormone has a ketone group at C3 and a double bond between C4 and C5. In the liver their physiological activities are lost when ring A is reduced, and they are partially inactivated when the 11β-hydroxyl is oxidized to a ketone group (as in cortisone and 11-dehydro...
Temporal coordination of regulatory gene expression by the steroid hormone ecdysone. In Drosophila, pulses of the steroid hormone ecdysone function as temporal signals that trigger the major postembryonic developmental transitions. The best... Karim, F.D.,Thummel, C.S. - 《Embo Journal》 被引量...
a multi-step innate behavior ofDrosophilalarvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dil...
This family includes receptors for steroid hormones, thyroid hormones, hormonal forms of vitamin A and D, peroxisomal activators, and ecdysone. Molecular cloning and structure/function analyses have revealed that all members of the steroid/thyroid hormone/retinoic acid receptor family have a similar fun...
The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having i