We used a conditional deletion model to remove Vlk in limb bud mesenchyme ( Vlk‐Prx1 cKO) to assess the specific requirement for Vlk expression by skeletal progenitor cells during endochondral ossification, and an inducible global deletion model ( Vlk‐Ubq iKO) to address the role of Vlk ...
As a first step toward addressing these questions, we examined the bone microstructure ofPappochelys rosinae. To this end, we have sectioned limb-bones, vertebrae, ribs, and gastralia of this taxon and also employed micro-CT-scanning data. Microanatomy ofPappochelyshas then been compared with ...
Thus, we analyzed the spatio-temporal immunolocalization of VEGF-A and its relationship with Runt-related transcription factor 2 (Runx2) and osterix (Osx) during the early steps of intramembranous ossification of the alveolar process in rat embryos. Embryo heads (E) of 16, 18 and 20-day-old...
In addition, Yap1 also governs the initiation of fracture repair by inhibition of cartilaginous callus tissue formation. Taken together, our work provides insights into the mechanism by which Yap1 regulates endochondral ossification, which may help the development of therapeutic treatment for bone ...
Purpose: The late stage of endochondral ossification including chondrocyte hypertrophy, cartilage matrix degradation, and vascular invasion is known to be crucial not only in physiological skeletal growth, but also in cartilage destruction and osteophyte formation during osteoarthritis progression. Since the ...
boneDuring endochondral ossification, the secreted growth factor Indian hedgehog (Ihh) regulates several differentiation steps. It interacts with a second secreted factor, parathyroid hormone-related protein (PTHrP), to regulate the onset of hypertrophic differentiation, and it regulates chondrocyte ...