According to several processes, we can see that PHM gets involved in many areas, such as sensor systems, failure mechanisms and algorithm designs. The implementation of PHM is a complicated course. Difficulties of making PHM come true are from many aspects. Firstly, it is related to integrated...
We systematically collected multiple samples as punches from the prostate in all cases based on histopathological evidence of tumour and from the seminal vesicles and lymph nodes where possible. We estimated cancer cell purities at 10–90% using the Battenberg algorithm (see methods). We also ...
Step and dwell distributions were extracted through a step-finding algorithm described in the Methods. Gaussian fits captured the overall step size distribution when multiples of 1 × and 2 × the fundamental step size were included for both positive and negative steps (Fig. 3a). Positive and ...
Relevantly, the cell-to-cell variability in the kinetics of a chemical process depends not only on the variability in the numbers of the molecules involved, but also on the complexity of the process. For example, in a multi-step process such as transcription6,20,21,22,23, the degree to ...
While the early phase of my research involved sitting in galleries and museums, viewingimagesand objects in the flesh, during the pandemic I had to retreat home and recalibrate how I could access these visual prompts. I made use of books and postcard reproductions of artworks and also looked...
Because the hash value in each step (other than the first) includes information about the hash value generated in the previous step, the hash value implicitly identifies the entire history of the processing steps involved in a workflow up to that point. Accordingly, in some embodiments, the ...
Further challenges and open questions remain regarding the incorporation of oral SERDs and other novel ETs in the treatment algorithm of mBC. First, it would be very important to study the activity and efficacy of oral SERDs also in pre-menopausal women, as many trials, including the EMERALD, ...
HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confe
we found high structural similarity between the unknown domain of the single-standing NRPS AlbIV, which was hypothesized to catalyze dehydration of l-asparagine9, with the 38 kDa domain found inserted in the stand-alone NRPS CysH (69% identity/83% similarity), which is involved in cystobact...
TM11 and TM12 wrap around the core of the protein. Both TM1 and TM6 are discontinuous and consist of two short alpha-helices (TM1a, TM1b; TM6a, TM6b) connected by a highly conserved unwound segment which is involved in the substrate binding site and therefore in the transport translocat...