The template proteins are the reference protein structures. In homology modeling, you match your targetprotein with all of the related protein structuresthat are present in the various databases using simple sequence alignment software. Select the proteins that are most closely related to your target ...
Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement The structure of The structure of Plasmodium vivax dihydrofolate reductase, a potential target for antimalarial therapy, is described. G Rastelli,S Pacchioni,MD Parenti - 《Bioorganic & Med...
Our aim was to build two complete Asc-1 homology models of the states, “outward-open” and “outward-open occluded” conformations. Given the lack of X-ray crystal structures involving Asc-1 in OO and OOO states, homology models were derived from the well-resolved multi-states of the rela...
pombe APN2 based on sequence homology [104]. The Nfo type APE is extremely unusual because it is a Zn metalloenzyme with a 3-Zn2+ center [105]. It does not require external Mg2+ for activity [92]. The evolutionary significance of the Nfo family is unclear. Mammalian cells express only...
Using the new benchmark dataset, we proposed a new predictor called "dRHP-GreyFun" based on the grey modeling and functional domain approach. Rigorous cross-validations have indicated that the new predictor is superior to its counterparts in both enhancing success rates and reducing computational ...
Using the new benchmark dataset, we proposed a new predictor called "dRHP-GreyFun" based on the grey modeling and functional domain approach. Rigorous cross-validations have indicated that the new predictor is superior to its counterparts in both enhancing success rates and reducing computational ...
Using in vitro experiments, we reconstitute the key biosynthetic steps of linker formation and shuttling via CysB to the NRPS. The biosynthetic logic involves a previously uncharacterized bifunctional domain found in the stand-alone NRPS module CysH, albicidin biosynthesis and numerous BGCs of unknown...
The human mitochondrial AAA+ protein LONP1 is a critical quality control protease involved in regulating diverse aspects of mitochondrial biology including proteostasis, electron transport chain activity, and mitochondrial transcription. As such, genetic or aging-associated imbalances in LONP1 activity are ...
(4.1 protein, ezrin, radixin and moesin homology domain). A common domain found in a number of proteins that mediate linkage of the cytoskeleton to the plasma membrane. The FERM domain often interacts with the cytoplasmic tail of transmembrane proteins. Pleckstrin homology domain A lipid-binding ...
Cellular regulation or signaling processes are mediated by many proteins which often have one or several intrinsically disordered regions (IDRs). These IDRs generally serve as binders to different proteins with high specificity. In many cases, IDRs under