BMMSCs were first discovered by Friedenstein et al.44as a subpopulation of non-haematopoietic stromal cells residing in bone marrow that were able to self-renew and differentiate into multiple cell types. Since then, BMMSCs have become the most extensively studied MSCs for bone regeneration due t...
Somatic stem cells Multipotent somatic or adult stem cells (SSC) are found in differentiated tissues. The natural function of these cells is the maintenance and regeneration of aged or damaged tissue by replacing lost cells [20]. In general these undifferentiated cells are found throughout the bod...
S. Aging induces aberrant state transition kinetics in murine muscle stem cells. Development 147, dev183855 (2020). Article CAS Google Scholar Aros, C. J. et al. Distinct spatiotemporally dynamic Wnt-secreting niches regulate proximal airway regeneration and aging. Cell Stem Cell 27, 413–429...
injury site to clear the debris. Schwann cells actively proliferate, elongate and align in columns to create a nutrient-rich environment to guide and support the axonal regeneration towards the periphery with a velocity of about 1 mm/day [27,28,29]. However, the ability of skeletal muscle and...
cells ( Table 1.Application of stem cells in regenerative medicine: stem cells (ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs) have diverse applications in tissue regeneration and disease therapeutics. Figure 1 Open in figure viewerPowerPoint...
They are expressed in cells that are generally not exposed to blood flow, such as subendothelial cells (e.g., smooth muscle cells), perivascular cells, and fibroblasts. MSCs have been shown to heterogeneously express TF [25], depending on tissue sources and culture conditions [26,27,28]. ...
Mesenchymal stem cells own self-renewal, differentiation, homing, immunomodulation and remains unaffected by the coronavirus on the virtue of the absence of ACE-2 receptors, indicating that MSC's could be used an ameliorative approach for COVID-19. MSCs have shown to combat the disease via ...
The classification of stem cells includes embryonic stem cells and adult stem cells, with the latter encompassing mesenchymal stem cells, hematopoietic stem cells, epidermal stem cells, and other types. As a type of versatile cell, stem cells possess the ability to both self-replicate and different...
Oxidative phosphorylation (OXPHOS) in the mitochondrial inner membrane is a therapeutic target in many diseases. Neural stem cells (NSCs) show progress in improving mitochondrial dysfunction in the central nervous system (CNS). However, translating neura
JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates. Development. 2019;146(2):dev167643. Article PubMed Central PubMed Google Scholar Jiang H, Tian A, Jiang J. Intestinal stem cell response to injury: lessons from Drosophila. Cell Mol Life Sci. 2016;73(17):...