There is general agreement, however, that a cell lacking nestin is unlikely to be a stem cell. Our data show unequivocally that in adherent cultures, the majority of cells are nestin positive, while in sphere culture, the same cell line generates a large population of nestin-negative cells. ...
Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation occurs during development of an organism to produce new specialised cells, and also in adults to ...
5.540.5.4Adult Stem Cells Adult stem cells, especiallyhematopoietic stem cells, are the best understood cell type in stemcell biology.74However, adult stem cell research remains an area of intense study, as their potential for therapy may be applicable to a myriad of degenerative disorders. Within...
Mesenchymal stem cells are non-hematopoietic multipotent precursor cells that can differentiate into a variety of cell types, including primary osteoblasts (bone cells), adipocytes (fat cells), and chondrocytes (cartilage cells). Reportedly, mesenchymal stem cells can also differentiate into myocytes (mu...
Stem cells are characterized by their ability to self-renew and differentiate into many different cell types. Research has focused primarily on how these processes are regulated at a transcriptional level. However, recent studies have indicated that stem cell behaviour is strongly coupled to the regul...
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The ...
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
Bone microvascular endothelial cells (BMECs) played an important role in the pathogenesis of glucocorticoid-induced osteonecrosis of femoral head (GCS-ONFH), and exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) may provide an effectiv
Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118–1129 (2008). This is the initial demonstration via label retention analysis that HSCs are dormant under steady state and cycle only five times per a mouse'...
Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component of stem cell potency, ov