最终筛选出来的8个“亚细胞系”具有正常的核型,相似的形态,但存活和增殖速率稍有差异。单细胞RNA测序显示它们均表达干细胞marker,且表达模式与未分化的干细胞一致,7个遗传背景不同的亚系中,有6个的转录组图谱极为相似。 图1 8个iPSC系...
骨髓间充质干细胞(mesenchymal stem cells,MSC):是干细胞家族的重要成员,来源于发育早期的中胚层和外胚层.MSC最初在骨髓中发现,因其具有多向分化潜能、造血支持和促进干细胞植入、免疫调控和自我复制等特点而日益受到人们的关注.如间充质干细胞在体内或体外特定的诱导条件下,可分化为脂肪、骨、软骨、肌肉、肌腱、韧...
Cellular Immortality and Cancer: From Telomerase to Cancer Stem Cells Calin O.Marian,Jerry W.Shay, inBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009 Another importantstem cell markeris prominin-1 (CD133), apentaspanmembrane proteinwith unclear function[22]. Collins et al...
Marker for stem cells.Methods and compositions are provided for the identification of stem cells, including neural, muscle and hair follicle stem cells. ...- (USPTO) - , , The Patent Description & Claims data below is from USPTO Patent Application 20090253147, Marker for stem cells.You can ...
2023年4月6日,中国科学院脑科学与智能技术卓越创新中心(神经科学研究所)刘真研究组、非人灵长类研究平台孙强研究团队与清华大学生命科学学院周帆研究组合作,在Cell Stem Cell期刊在线发表了题为:Cynomolgus monkey embryo model captures gastrulation and early pregnancy(食蟹猴胚胎模型体外培养发育到原肠胚和引起早期妊...
肌肉干细胞(Muscle stem cells,MuSC)也称为卫星细胞,位于肌纤维周边的微环境中,它们在骨骼肌维持和再生中发挥着重要作用。研究表明,与年龄相关的肌肉质量和力量下降(也称为肌少症)与MuSC功能障碍存在直接关系。然而,尚不清楚这种功能障碍的潜在机制,这限制了针对肌少症疗法的发展。骨骼肌微环境中的纤连蛋白、Wnt、...
Each month Nature Communications’ editors highlight new Articles they see as particularly interesting or important in the area of stem cells and disease.
43 Sca-1 is the most recognized HSC marker in mice with both Ly-6 haplotypes as it is expressed on multipotent HSCs.44, 45 An anti-Sca-1 Ab is frequently used in combination with negative selection for expression of a number of cell surface markers characteristic of differentiated cells of...
结果发现HAC处理的细胞表达了肝组细胞特有的marker,如 Krt19, Sox9 和 Afp。进一步RNA测序分析结果也表明,HT1-mCdHs细胞转录组范围的表现型与初始的原代肝细胞(HT1-mPHs)存在显著的差异,尤其是细胞周期相关的一些基因在HT1-mCdHs中显著升高。体内的肝祖细胞具有向成熟肝细胞和胆管细胞分化的能力,作者观察到HT1-mC...
2023年9月7日，来自中国科学院广州生物医药与健康研究院赖良学课题组联合该院潘光锦、Miguel A. Esteban课题组，在Cell Stem Cell杂志上发表了题为Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation的封面研究论文。该项研究报道利用具有高分化潜能、强竞争及...