Stem cells are characterized by their ability to self-renew and differentiate into many different cell types. Research has focused primarily on how these processes are regulated at a transcriptional level. However, recent studies have indicated that stem cell behaviour is strongly coupled to the regul...
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smoot...
A stem cell is functionally defined by its multipotency and self-renewing capacity.Intestinal stem cells’ progeny undergo lineage differentiation into the limited intestinal epithelial cell types. To achieve this, stem cells must divide to give rise to a daughter stem cell and a committed daughter...
Bone marrow cells are the best-known somatic-cell-derived stem cells, but the use of mesenchymal stem cells (MSCs) found in adipose tissue has also recently attracted attention. This paper will review the differentiation ability and mechanisms of these various stem cell types to hepatocytes and ...
近日,研究人员在Stem cell research & therapy上发表研究成果,系统揭示了hESC-Exo和hiPSC-Exos的蛋白组份和miRNA组份构成,并与人脐带间充质干细胞来源外泌体进行比对,为3种干细胞外泌体临床前和临床实验提供重要参考。 研究发现,三种...
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), play important roles in the growth, repair, a...
Endometrial stem/progenitor cells are a type of stem cells with the ability to self-renew and differentiate into multiple cell types. They exist in the end
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it
cell cortex traveled dramatically farther in ISCs from infected intestines than in controls. We asked whether other cell types were also capable of migration, and used the Su(H) and prospero promoters to identify post-mitotic precursor EBs and differentiated EEs, respectively. Only minimal protrusion...
dose-dependent change in the microtubule staining intensity could be observed for any of the investigated cell types (Fig.3b). Therefore, no correlation could be detected between the observed reduction in migratory velocity and any alterations in the cytoskeletal architecture for any of the cell ...