Supporting this concept, it was demonstrated in a murine model that mesenchymal stem cell transplantation leads to permanent donor-specific immunotolerance in allogeneic hosts and results in long-term allogeneic skin graft acceptance [124]. Other studies have shown that mesenchymal stem cells are ...
Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as therapies for a variety of disorders in lates
Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations. Blood. 2017;130:1456–67. https://doi.org/10.1182/blood-2017-03-771600. Article PubMed PubMed Central CAS Google Scholar Barzaghi F, Amaya Hernandez LC, Neven B, et al. Long-term follow...
Stem Cell Res Ther 13, 101 (2022). https://doi.org/10.1186/s13287-022-02782-7 Bari E, Ferrarotti I, Saracino L, Perteghella S, Torre ML, Richeldi L, Corsico AG. Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Therapy to Treat the Long-Term Lung ...
Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The...
Racke, MD; Jaime Imitola, MD JAMA Neurology Podcast (8:02) Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis (JAMA Neurology) 1x 0:00 / 0:00 Key Points Question What are the long-term outcomes after autologous hematopoietic stem cell transplantation for the treatment of ...
Similar to the majority of treatments, cell therapy could be accompanied by side effects, particularly in stem cell therapy [76]. For instance, prior to using stem cells, they should be grown for several months after they are harvested from embryos. Further, painful procedures are experienced wh...
Their extensive use over the long term is hindered by potential side e ffects10–13. Therefore, the development of alternative therapies, offering new and fundamental approaches, becomes imperative. In recent years, stem cell therapy has been proposed as an alternative for the treatment of ...
Stem cell factor (SCF) is a cytokine that regulates hematopoiesis and other biological processes. While clinical treatments using SCF would be highly beneficial, these have been limited by toxicity related to mast cell activation. Transmembrane SCF (tmSC
and effectively, it is indispensable to accumulate the clinical efficacy and long-term safety data. More specifically, for the clinical trials, the information on the MSCs dosage and application methods serves as the prerequisite for bringing the MSC-based therapy in AR animal models into the clini...