Sara C. ParkeDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Phoenix, AZ;Touré BarksdaleDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN;Aliea E. HerbertDepartment of Physical Medicine and Rehabilitation, Swedish Cancer Institute, Seattle, WA;Vishal Bansal...
Adult Blood & Marrow Transplant Program, CLL Disease Working Group, Hematology and Oncology Fellowship Program, Mayo Clinic, Phoenix, AZ, USA Jose F. Leis Center for Hematologic Malignancies, Adult Blood and Marrow Transplant & Cell Therapy Program, Knight Cancer Institute, Oregon Health & Science ...
two patients developed neurologic injury after VST infusion for disseminated adenoviral infection. Immune effector associated neurologic syndrome (ICANS) is well-described after CD19 chimeric antigen receptor (CAR) T cell therapy75
At the transcriptome level, LSKs constitute a heterogeneous cell population, comprised of cell fractions that are seemingly primed for further HSPC-lineage differentiation39. Thus, to assess if the miR-142 deficit affected the BM LSC-enriched LSK landscape, we utilized single cell (sc) RNA-seq a...
[34]. Patient-derived cell line GB7 was established from resected primary GBM tumor tissue at the Barrow Neurological Institute, Phoenix, AZ, USA. These GSLCs were grown as neurospheres (Gibco) in DMEM and F12-Glutamax (Gibco) supplemented with B27 (Thermo Fisher Scientific; Waltham, MA, ...
While there is no cure for SLE, MSC transplantation, in recent clinical trials, shows promising results as a novel cell therapy. Intravenous injection of allogeneic UC-MSCs in 39 patients with active SLE twice in a 1-week interval showed a significant decrease in the SLE disease activity index...
In humans, loss of miR-142 function has been reportedly associated with blood cancers. Mutations and/or downregulation of miR-142 have been found in follicular and diffuse large B cell lymphoma and acute lymphocytic leukemia (ALL)18. More recently,MIR142was found to be mutated or downregulated ...
Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demonstrated with aggressiveness of pancreatic cancer. In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which ...