PLANT growthPLURIPOTENT stem cellsLIFE cycles (Biology)The development of both animals and plants relies on populations of pluripotent stem cells that provide the cellular raw materials for organ and tissue formation. Plant stem cell reservoirs are housed at the shoot and root tips in struct...
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate ...
By definition, an adult stem cell is a cell that comes from a given organ, has a long-term replicative potential and the ability to both self-renew and differentiate into the cellular components of the organ. From:Annals of Oncology,2006 ...
the shoot apical cell showed normal spiral cell division while initiation of leaf primordia was severely suppressed resulting in the formation of a raspberry-like dome of cells. Thus, auxin distribution is also crucial for normal organ initiation...
2024年4月30日,美国南加州大学凯克医学院博徳干细胞研究所李中伟组在Cell Stem Cell杂志上发表报道一种新的二维培养方法,通过小分子化合物调控p38和YAP信号通路,实现长期体外扩增培养原代小鼠肾单元祖细胞,人原代肾单元祖细胞及人多能干细胞...
Hair follicles, mammalian mini-organs that grow hair, miniaturize during aging, leading to hair thinning and loss. Here we report that hair follicle stem cells (HFSCs) lose their regenerative capabilities during aging owing to the adoption of an atypical
The development of any stem-cell-based therapy (and a potential one for deafness is no exception) relies on the generation of the necessary tools: 'cell drugs' that can be safely manufactured for their clinical application. An increasing body of work has focussed on the identification, in anim...
生物通报道,美国密苏里州斯托瓦斯医学研究所(Stowers Institute for Medical Research),堪萨斯大学医学院解剖与细胞生物学系的解廷教授在最新一期的《Cell Stem Cell》上发表评述文章Stem Cell in the Adult Drosophila Hindgut: Just a Sleeping Beauty,点评本期《Cell Stem Cell》发表的一篇研究性文章The Drosophila Hi...
近日,来自瑞士诺华制药公司的Jan S. Tchorz团队在Cell Stem Cell杂志上发表了文章NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo,他们报告了一种具...
the signaling molecules used within stem cell niches are often the same used to organize growth and tissue patterning during embryogenesis, such as homologues of the Notch, Wingless and Hedgehog proteins fromDrosophila(Orford & Scadden 2008; He, Nakada, & Morrison 2009). Plant genomes do not con...